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2icw

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(New page: 200px<br /> <applet load="2icw" size="450" color="white" frame="true" align="right" spinBox="true" caption="2icw, resolution 2.410&Aring;" /> '''Crystal structure ...)
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Revision as of 20:37, 12 November 2007

Image:2icw.gif

2icw, resolution 2.410Å

Drag the structure with the mouse to rotate

Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule

Overview

'Superantigens' (SAgs) trigger the massive activation of T cells by, simultaneous interactions with MHC and TCR receptors, leading to human, diseases. Here we present the first crystal structure, at 2.5-A, resolution, of a complete ternary complex between a SAg and its two, receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg, Mycoplasma arthritidis mitogen, unlike others, has direct contacts not, only with TCR Vbeta but with TCR Valpha.

About this Structure

2ICW is a Protein complex structure of sequences from Homo sapiens, Mus musculus and Mycoplasma arthritidis. Full crystallographic information is available from OCA.

Reference

Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC., Wang L, Zhao Y, Li Z, Guo Y, Jones LL, Kranz DM, Mourad W, Li H, Nat Struct Mol Biol. 2007 Feb;14(2):169-71. Epub 2007 Jan 14. PMID:17220897

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