2eu3

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[[Image:2eu3.gif|left|200px]]
[[Image:2eu3.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2eu3 |SIZE=350|CAPTION= <scene name='initialview01'>2eu3</scene>, resolution 1.6&Aring;
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The line below this paragraph, containing "STRUCTURE_2eu3", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FF3:1-(5-AMINO-1,3,4-THIADIAZOL-2-YL)-1,1-DIFLUOROMETHANESULFONAMIDE'>FF3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2eu3| PDB=2eu3 | SCENE= }}
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|RELATEDENTRY=[[2eu2|2EU2]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eu3 OCA], [http://www.ebi.ac.uk/pdbsum/2eu3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2eu3 RCSB]</span>
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}}
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'''Human Carbonic anhydrase II in complex with novel inhibitors'''
'''Human Carbonic anhydrase II in complex with novel inhibitors'''
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[[Category: McKenna, R.]]
[[Category: McKenna, R.]]
[[Category: Silverman, D N.]]
[[Category: Silverman, D N.]]
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[[Category: carbonic anhydrase ii proton transfer inhibitor]]
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[[Category: Carbonic anhydrase ii proton transfer inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:06:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:53:46 2008''
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Revision as of 00:07, 4 May 2008

Image:2eu3.gif

Template:STRUCTURE 2eu3

Human Carbonic anhydrase II in complex with novel inhibitors


Contents

Overview

Human carbonic anhydrases (CAs) are well studied targets for the development of inhibitors for pharmaceutical applications. The crystal structure of human CA II has been determined in complex with two CA inhibitors (CAIs) containing conventional sulfonamide and thiadiazole moieties separated by a -CF2- or -CHNH2- spacer group. The structures presented here reveal that these spacer groups allow novel binding modes for the thiadiazole moiety compared with conventional CAIs.

Disease

Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[611492]

About this Structure

2EU3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes., Fisher SZ, Govindasamy L, Boyle N, Agbandje-McKenna M, Silverman DN, Blackburn GM, McKenna R, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):618-22. Epub 2006 Jun 10. PMID:16820676 Page seeded by OCA on Sun May 4 03:06:59 2008

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OCA

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