2evu

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[[Image:2evu.gif|left|200px]]
[[Image:2evu.gif|left|200px]]
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{{Structure
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|PDB= 2evu |SIZE=350|CAPTION= <scene name='initialview01'>2evu</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_2evu", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|GENE= aqpM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=145262 Methanothermobacter thermautotrophicus])
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{{STRUCTURE_2evu| PDB=2evu | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2evu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2evu OCA], [http://www.ebi.ac.uk/pdbsum/2evu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2evu RCSB]</span>
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'''Crystal structure of aquaporin AqpM at 2.3A resolution'''
'''Crystal structure of aquaporin AqpM at 2.3A resolution'''
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[[Category: Remis, J.]]
[[Category: Remis, J.]]
[[Category: Stroud, R M.]]
[[Category: Stroud, R M.]]
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[[Category: alpha-helical]]
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[[Category: Alpha-helical]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:10:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:54:32 2008''
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Revision as of 00:10, 4 May 2008

Image:2evu.gif

Template:STRUCTURE 2evu

Crystal structure of aquaporin AqpM at 2.3A resolution


Overview

To explore the structural basis of the unique selectivity spectrum and conductance of the transmembrane channel protein AqpM from the archaeon Methanothermobacter marburgensis, we determined the structure of AqpM to 1.68-A resolution by x-ray crystallography. The structure establishes AqpM as being in a unique subdivision between the two major subdivisions of aquaporins, the water-selective aquaporins, and the water-plus-glycerol-conducting aquaglyceroporins. In AqpM, isoleucine replaces a key histidine residue found in the lumen of water channels, which becomes a glycine residue in aquaglyceroporins. As a result of this and other side-chain substituents in the walls of the channel, the channel is intermediate in size and exhibits differentially tuned electrostatics when compared with the other subfamilies.

About this Structure

2EVU is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.

Reference

Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A., Lee JK, Kozono D, Remis J, Kitagawa Y, Agre P, Stroud RM, Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18932-7. Epub 2005 Dec 16. PMID:16361443 Page seeded by OCA on Sun May 4 03:10:14 2008

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