2f0r

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[[Image:2f0r.gif|left|200px]]
[[Image:2f0r.gif|left|200px]]
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{{Structure
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|PDB= 2f0r |SIZE=350|CAPTION= <scene name='initialview01'>2f0r</scene>, resolution 2.26&Aring;
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The line below this paragraph, containing "STRUCTURE_2f0r", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= TSG101 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2f0r| PDB=2f0r | SCENE= }}
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|RELATEDENTRY=[[1s1q|1S1Q]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f0r OCA], [http://www.ebi.ac.uk/pdbsum/2f0r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f0r RCSB]</span>
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'''Crystallographic structure of human Tsg101 UEV domain'''
'''Crystallographic structure of human Tsg101 UEV domain'''
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[[Category: Mateo, P L.]]
[[Category: Mateo, P L.]]
[[Category: Palencia, A]]
[[Category: Palencia, A]]
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[[Category: tsg101]]
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[[Category: Tsg101]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:19:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:56:20 2008''
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Revision as of 00:19, 4 May 2008

Image:2f0r.gif

Template:STRUCTURE 2f0r

Crystallographic structure of human Tsg101 UEV domain


Contents

Overview

The UEV domain of the TSG101 protein functions in the vacuolar protein-sorting pathway and in the budding process of HIV-1 and other retroviruses by recognizing ubiquitin in proteins tagged for degradation and short sequences in viral proteins containing an essential and well conserved PTAP motif, respectively. A deep understanding of these interactions is key to the rational design of much-needed novel antivirals. Here, the crystal structure of the TSG101 UEV domain (TSG101-UEV) is presented. TSG101-UEV was crystallized in the presence of PEG 4000 and ammonium sulfate. Under these conditions, crystals were obtained in space group R3, with unit-cell parameters a = b = 97.9, c = 110.6 A, alpha = beta = 90, gamma = 120 degrees . Phases were solved by molecular replacement and the crystal structure of TSG101-UEV was refined to an R factor of 18.8% at 2.2 A resolution. A comparison between the crystal structure and previously reported NMR structures has revealed significant differences in the conformation of one of the loops implicated in ubiquitin recognition. Also, the resulting structure has provided information about the presence of water molecules at the binding interface that could be of relevance for peptide recognition.

Disease

Known disease associated with this structure: Breast cancer OMIM:[601387]

About this Structure

2F0R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human TSG101 UEV domain., Palencia A, Martinez JC, Mateo PL, Luque I, Camara-Artigas A, Acta Crystallogr D Biol Crystallogr. 2006 Apr;62(Pt 4):458-64. Epub 2006, Mar 18. PMID:16552148 Page seeded by OCA on Sun May 4 03:19:30 2008

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