2f1d

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[[Image:2f1d.gif|left|200px]]
[[Image:2f1d.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2f1d |SIZE=350|CAPTION= <scene name='initialview01'>2f1d</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2f1d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Imidazoleglycerol-phosphate_dehydratase Imidazoleglycerol-phosphate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.19 4.2.1.19] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2f1d| PDB=2f1d | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f1d OCA], [http://www.ebi.ac.uk/pdbsum/2f1d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f1d RCSB]</span>
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}}
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'''X-Ray Structure of imidazoleglycerol-phosphate dehydratase'''
'''X-Ray Structure of imidazoleglycerol-phosphate dehydratase'''
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[[Category: Rice, D W.]]
[[Category: Rice, D W.]]
[[Category: Sedelnikova, S E.]]
[[Category: Sedelnikova, S E.]]
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[[Category: herbicide]]
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[[Category: Herbicide]]
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[[Category: histidine biosynthesis]]
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[[Category: Histidine biosynthesis]]
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[[Category: igpd]]
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[[Category: Igpd]]
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[[Category: manganese]]
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[[Category: Manganese]]
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[[Category: x-ray crystallography]]
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[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:20:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:56:35 2008''
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Revision as of 00:20, 4 May 2008

Image:2f1d.gif

Template:STRUCTURE 2f1d

X-Ray Structure of imidazoleglycerol-phosphate dehydratase


Overview

The structure of A. thaliana imidazoleglycerol-phosphate dehydratase, an enzyme of histidine biosynthesis and a target for the triazole phosphonate herbicides, has been determined to 3.0 A resolution. The structure is composed of 24 identical subunits arranged in 432 symmetry and shows how the formation of a novel dimanganese cluster is crucial to the assembly of the active 24-mer from an inactive trimeric precursor and to the formation of the active site of the enzyme. Molecular modeling suggests that the substrate is bound to the manganese cluster as an imidazolate moiety that subsequently collapses to yield a diazafulvene intermediate. The mode of imidazolate recognition exploits pseudosymmetry at the active site arising from a combination of the assembly of the particle and the pseudosymmetry present in each subunit as a result of gene duplication. This provides an intriguing example of the role of evolution in the design of Nature's catalysts.

About this Structure

2F1D is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of imidazoleglycerol-phosphate dehydratase., Glynn SE, Baker PJ, Sedelnikova SE, Davies CL, Eadsforth TC, Levy CW, Rodgers HF, Blackburn GM, Hawkes TR, Viner R, Rice DW, Structure. 2005 Dec;13(12):1809-17. PMID:16338409 Page seeded by OCA on Sun May 4 03:20:51 2008

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