2f2l

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[[Image:2f2l.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2l OCA], [http://www.ebi.ac.uk/pdbsum/2f2l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f2l RCSB]</span>
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'''Crystal structure of tracheal cytotoxin (TCT) bound to the ectodomain complex of peptidoglycan recognition proteins LCa (PGRP-LCa) and LCx (PGRP-LCx)'''
'''Crystal structure of tracheal cytotoxin (TCT) bound to the ectodomain complex of peptidoglycan recognition proteins LCa (PGRP-LCa) and LCx (PGRP-LCx)'''
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[[Category: Chang, C I.]]
[[Category: Chang, C I.]]
[[Category: Deisenhofer, J.]]
[[Category: Deisenhofer, J.]]
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[[Category: protein-peptidoglycan complex]]
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[[Category: Protein-peptidoglycan complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:23:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:57:03 2008''
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Revision as of 00:23, 4 May 2008

Image:2f2l.gif

Template:STRUCTURE 2f2l

Crystal structure of tracheal cytotoxin (TCT) bound to the ectodomain complex of peptidoglycan recognition proteins LCa (PGRP-LCa) and LCx (PGRP-LCx)


Overview

Tracheal cytotoxin (TCT), a naturally occurring fragment of Gram-negative peptidoglycan, is a potent elicitor of innate immune responses in Drosophila. It induces the heterodimerization of its recognition receptors, the peptidoglycan recognition proteins (PGRPs) LCa and LCx, which activates the immune deficiency pathway. The crystal structure at 2.1 angstrom resolution of TCT in complex with the ectodomains of PGRP-LCa and PGRP-LCx shows that TCT is bound to and presented by the LCx ectodomain for recognition by the LCa ectodomain; the latter lacks a canonical peptidoglycan-docking groove conserved in other PGRPs. The interface, revealed in atomic detail, between TCT and the receptor complex highlights the importance of the anhydro-containing disaccharide in bridging the two ectodomains together and the critical role of diaminopimelic acid as the specificity determinant for PGRP interaction.

About this Structure

2F2L is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor., Chang CI, Chelliah Y, Borek D, Mengin-Lecreulx D, Deisenhofer J, Science. 2006 Mar 24;311(5768):1761-4. PMID:16556841 Page seeded by OCA on Sun May 4 03:23:31 2008

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