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2f3k

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[[Image:2f3k.jpg|left|200px]]
[[Image:2f3k.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2f3k |SIZE=350|CAPTION= <scene name='initialview01'>2f3k</scene>, resolution 1.599&Aring;
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The line below this paragraph, containing "STRUCTURE_2f3k", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RO1:(3S,4AS,8AS)-N-(TERT-BUTYL)-2-[(3S)-3-({3-(METHYLSULFONYL)-N-[(PYRIDIN-3-YLOXY)ACETYL]-L-VALYL}AMINO)-2-OXO-4-PHENYLBUTYL]DECAHYDROISOQUINOLINE-3-CARBOXAMIDE'>RO1</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2f3k| PDB=2f3k | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3k OCA], [http://www.ebi.ac.uk/pdbsum/2f3k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f3k RCSB]</span>
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}}
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'''Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease'''
'''Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease'''
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[[Category: Prabu-Jeyabalan, M.]]
[[Category: Prabu-Jeyabalan, M.]]
[[Category: Schiffer, C A.]]
[[Category: Schiffer, C A.]]
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[[Category: drug resistance]]
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[[Category: Drug resistance]]
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[[Category: hiv protease]]
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[[Category: Hiv protease]]
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[[Category: ro1]]
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[[Category: Ro1]]
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[[Category: substrate envelope]]
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[[Category: Substrate envelope]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:25:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:57:27 2008''
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Revision as of 00:25, 4 May 2008

Image:2f3k.jpg

Template:STRUCTURE 2f3k

Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease


Overview

In our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved "envelope" that appears to be important for substrate recognition and the selection of drug-resistant mutations. In this study, the complex of HIV-1 protease with the inhibitor RO1 was determined and comparison with the substrate envelope provides a rationale for mutational patterns.

About this Structure

2F3K is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease., Prabu-Jeyabalan M, King NM, Nalivaika EA, Heilek-Snyder G, Cammack N, Schiffer CA, Antimicrob Agents Chemother. 2006 Apr;50(4):1518-21. PMID:16569872 Page seeded by OCA on Sun May 4 03:25:25 2008

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