2f3k

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2f3k.jpg|left|200px]]
[[Image:2f3k.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2f3k |SIZE=350|CAPTION= <scene name='initialview01'>2f3k</scene>, resolution 1.599&Aring;
+
The line below this paragraph, containing "STRUCTURE_2f3k", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RO1:(3S,4AS,8AS)-N-(TERT-BUTYL)-2-[(3S)-3-({3-(METHYLSULFONYL)-N-[(PYRIDIN-3-YLOXY)ACETYL]-L-VALYL}AMINO)-2-OXO-4-PHENYLBUTYL]DECAHYDROISOQUINOLINE-3-CARBOXAMIDE'>RO1</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2f3k| PDB=2f3k | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3k OCA], [http://www.ebi.ac.uk/pdbsum/2f3k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f3k RCSB]</span>
+
-
}}
+
'''Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease'''
'''Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease'''
Line 32: Line 29:
[[Category: Prabu-Jeyabalan, M.]]
[[Category: Prabu-Jeyabalan, M.]]
[[Category: Schiffer, C A.]]
[[Category: Schiffer, C A.]]
-
[[Category: drug resistance]]
+
[[Category: Drug resistance]]
-
[[Category: hiv protease]]
+
[[Category: Hiv protease]]
-
[[Category: ro1]]
+
[[Category: Ro1]]
-
[[Category: substrate envelope]]
+
[[Category: Substrate envelope]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:25:25 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:57:27 2008''
+

Revision as of 00:25, 4 May 2008

Image:2f3k.jpg

Template:STRUCTURE 2f3k

Substrate envelope and drug resistance: crystal structure of r01 in complex with wild-type hiv-1 protease


Overview

In our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved "envelope" that appears to be important for substrate recognition and the selection of drug-resistant mutations. In this study, the complex of HIV-1 protease with the inhibitor RO1 was determined and comparison with the substrate envelope provides a rationale for mutational patterns.

About this Structure

2F3K is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease., Prabu-Jeyabalan M, King NM, Nalivaika EA, Heilek-Snyder G, Cammack N, Schiffer CA, Antimicrob Agents Chemother. 2006 Apr;50(4):1518-21. PMID:16569872 Page seeded by OCA on Sun May 4 03:25:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f3k"
Personal tools