2f40
From Proteopedia
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'''Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction''' | '''Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction''' | ||
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[[Category: Prestegard, J H.]] | [[Category: Prestegard, J H.]] | ||
[[Category: SECSG, Southeast Collaboratory for Structural Genomics.]] | [[Category: SECSG, Southeast Collaboratory for Structural Genomics.]] | ||
| - | [[Category: | + | [[Category: Protein structure initiative]] |
| - | [[Category: | + | [[Category: Protein structure prediction]] |
| - | [[Category: | + | [[Category: Psi]] |
| - | [[Category: | + | [[Category: Pyrococcus furious]] |
| - | [[Category: | + | [[Category: Residual dipolar coupling]] |
| - | [[Category: | + | [[Category: Secsg]] |
| - | [[Category: | + | [[Category: Simulated annealing]] |
| - | [[Category: | + | [[Category: Southeast collaboratory for structural genomic]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:26:16 2008'' | |
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Revision as of 00:26, 4 May 2008
Structure of a Novel Protein from Backbone-Centered NMR Data and NMR-Assisted Structure Prediction
Overview
Targeting of proteins for structure determination in structural genomic programs often includes the use of threading and fold recognition methods to exclude proteins belonging to well-populated fold families, but such methods can still fail to recognize preexisting folds. The authors illustrate here a method in which limited amounts of structural data are used to improve an initial homology search and the data are subsequently used to produce a structure by data-constrained refinement of an identified structural template. The data used are primarily NMR-based residual dipolar couplings, but they also include additional chemical shift and backbone-nuclear Overhauser effect data. Using this methodology, a backbone structure was efficiently produced for a 10 kDa protein (PF1455) from Pyrococcus furiosus. Its relationship to existing structures and its probable function are discussed.
About this Structure
2F40 is a Single protein structure of sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA.
Reference
Structure determination of a new protein from backbone-centered NMR data and NMR-assisted structure prediction., Mayer KL, Qu Y, Bansal S, LeBlond PD, Jenney FE Jr, Brereton PS, Adams MW, Xu Y, Prestegard JH, Proteins. 2006 Nov 1;65(2):480-9. PMID:16927360 Page seeded by OCA on Sun May 4 03:26:16 2008
Categories: Pyrococcus furiosus | Single protein | Bansal, S. | Prestegard, J H. | SECSG, Southeast Collaboratory for Structural Genomics. | Protein structure initiative | Protein structure prediction | Psi | Pyrococcus furious | Residual dipolar coupling | Secsg | Simulated annealing | Southeast collaboratory for structural genomic | Structural genomic
