2f7k

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2f7k.gif|left|200px]]
[[Image:2f7k.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2f7k |SIZE=350|CAPTION= <scene name='initialview01'>2f7k</scene>, resolution 2.8&Aring;
+
The line below this paragraph, containing "STRUCTURE_2f7k", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyridoxal_kinase Pyridoxal kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.35 2.7.1.35] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2f7k| PDB=2f7k | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f7k OCA], [http://www.ebi.ac.uk/pdbsum/2f7k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f7k RCSB]</span>
+
-
}}
+
'''Crystal Structure of Human Pyridoxal Kinase'''
'''Crystal Structure of Human Pyridoxal Kinase'''
Line 30: Line 27:
[[Category: Jiang, T.]]
[[Category: Jiang, T.]]
[[Category: Tang, L.]]
[[Category: Tang, L.]]
-
[[Category: alpha-beta structure]]
+
[[Category: Alpha-beta structure]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:33:22 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:59:00 2008''
+

Revision as of 00:33, 4 May 2008

Image:2f7k.gif

Template:STRUCTURE 2f7k

Crystal Structure of Human Pyridoxal Kinase


Overview

Pyridoxal kinase, a member of the ribokinase superfamily, catalyzes the ATP-dependent phosphorylation reaction of vitamin B6 and is an essential enzyme in the formation of pyridoxal-5'-phosphate, a key cofactor for over 100 enzymes. Pyridoxal kinase is thus regarded as a potential target for pharmacological agents. In this paper, we report the 2.8 angstroms crystal structure of human pyridoxal kinase (HPLK) expressed in Escherichia coli. The diffraction data revealed unexpected merohedral perfect twinning along the crystallographic c axis. Taking perfect twinning into account, the structure in dimeric form was well refined according to the CNS program. Structure comparison reveals that the key 12-residue peptide over the active site in HPLK is a beta-strand/loop/beta-strand flap, while the corresponding peptide in sheep brain enzyme adopts a loop conformation. Moreover, HPLK possesses a more hydrophobic ATP-binding pocket. This structure will facilitate further biochemical studies and structure-based design of drugs related to pyridoxal kinase.

About this Structure

2F7K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human pyridoxal kinase., Cao P, Gong Y, Tang L, Leung YC, Jiang T, J Struct Biol. 2006 Jun;154(3):327-32. Epub 2006 Mar 20. PMID:16600635 Page seeded by OCA on Sun May 4 03:33:22 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f7k"
Personal tools