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2f83

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[[Image:2f83.gif|left|200px]]
[[Image:2f83.gif|left|200px]]
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{{Structure
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|PDB= 2f83 |SIZE=350|CAPTION= <scene name='initialview01'>2f83</scene>, resolution 2.87&Aring;
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The line below this paragraph, containing "STRUCTURE_2f83", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] </span>
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2f83| PDB=2f83 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f83 OCA], [http://www.ebi.ac.uk/pdbsum/2f83 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f83 RCSB]</span>
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'''Crystal structure of a human coagulation factor'''
'''Crystal structure of a human coagulation factor'''
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[[Category: Papagrigoriou, E.]]
[[Category: Papagrigoriou, E.]]
[[Category: Walsh, P N.]]
[[Category: Walsh, P N.]]
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[[Category: apple domain]]
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[[Category: Apple domain]]
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[[Category: protease]]
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[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:34:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:59:11 2008''
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Revision as of 00:34, 4 May 2008

Image:2f83.gif

Template:STRUCTURE 2f83

Crystal structure of a human coagulation factor


Overview

Factor XI (FXI), a coagulation protein essential to normal hemostasis, circulates as a disulfide-linked dimer. Here we report the full-length FXI zymogen crystal structure, revealing that the protease and four apple domains assemble into a unique 'cup and saucer' architecture. The structure shows that the thrombin and platelet glycoprotein Ib binding sites are remote within the monomer but lie in close proximity across the dimer, suggesting a transactivation mechanism.

About this Structure

2F83 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the factor XI zymogen reveals a pathway for transactivation., Papagrigoriou E, McEwan PA, Walsh PN, Emsley J, Nat Struct Mol Biol. 2006 Jun;13(6):557-8. Epub 2006 May 14. PMID:16699514 Page seeded by OCA on Sun May 4 03:34:31 2008

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