2f9b

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[[Image:2f9b.gif|left|200px]]
[[Image:2f9b.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2f9b |SIZE=350|CAPTION= <scene name='initialview01'>2f9b</scene>, resolution 2.54&Aring;
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The line below this paragraph, containing "STRUCTURE_2f9b", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=N1H:{5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3&#39;-NITRO-BIPHENYL-3-YL]-ACETIC+ACID'>N1H</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= F7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), F3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2f9b| PDB=2f9b | SCENE= }}
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|RELATEDENTRY=[[1o5d|1O5D]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f9b OCA], [http://www.ebi.ac.uk/pdbsum/2f9b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f9b RCSB]</span>
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}}
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'''Discovery of Novel Heterocyclic Factor VIIa Inhibitors'''
'''Discovery of Novel Heterocyclic Factor VIIa Inhibitors'''
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[[Category: Young, W B.]]
[[Category: Young, W B.]]
[[Category: Yu, C.]]
[[Category: Yu, C.]]
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[[Category: active site-directed inhibitor]]
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[[Category: Active site-directed inhibitor]]
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[[Category: serine protease]]
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[[Category: Serine protease]]
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[[Category: short hydrogen bond]]
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[[Category: Short hydrogen bond]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:37:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:59:45 2008''
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Revision as of 00:37, 4 May 2008

Image:2f9b.gif

Template:STRUCTURE 2f9b

Discovery of Novel Heterocyclic Factor VIIa Inhibitors


Contents

Overview

Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridine scaffold.

Disease

Known disease associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]

About this Structure

2F9B is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of novel heterocyclic factor VIIa inhibitors., Rai R, Kolesnikov A, Sprengeler PA, Torkelson S, Ton T, Katz BA, Yu C, Hendrix J, Shrader WD, Stephens R, Cabuslay R, Sanford E, Young WB, Bioorg Med Chem Lett. 2006 Apr 15;16(8):2270-3. Epub 2006 Feb 3. PMID:16460932 Page seeded by OCA on Sun May 4 03:37:14 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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