2f9t

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[[Image:2f9t.gif|left|200px]]
[[Image:2f9t.gif|left|200px]]
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{{Structure
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|PDB= 2f9t |SIZE=350|CAPTION= <scene name='initialview01'>2f9t</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_2f9t", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span>
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{{STRUCTURE_2f9t| PDB=2f9t | SCENE= }}
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|RELATEDENTRY=[[2f9w|2F9W]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f9t OCA], [http://www.ebi.ac.uk/pdbsum/2f9t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f9t RCSB]</span>
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'''Structure of the type III CoaA from Pseudomonas aeruginosa'''
'''Structure of the type III CoaA from Pseudomonas aeruginosa'''
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[[Category: White, S W.]]
[[Category: White, S W.]]
[[Category: Yun, M K.]]
[[Category: Yun, M K.]]
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[[Category: coaa]]
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[[Category: Coaa]]
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[[Category: pantothenate kinase]]
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[[Category: Pantothenate kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:38:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:59:56 2008''
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Revision as of 00:38, 4 May 2008

Image:2f9t.gif

Template:STRUCTURE 2f9t

Structure of the type III CoaA from Pseudomonas aeruginosa


Overview

Three distinct isoforms of pantothenate kinase (CoaA) in bacteria catalyze the first step in coenzyme A biosynthesis. The structures of the type II (Staphylococcus aureus, SaCoaA) and type III (Pseudomonas aeruginosa, PaCoaA) enzymes reveal that they assemble nearly identical subunits with actin-like folds into dimers that exhibit distinct biochemical properties. PaCoaA has a fully enclosed pantothenate binding pocket and requires a monovalent cation to weakly bind ATP in an open cavity that does not interact with the adenine nucleotide. Pantothenate binds to an open pocket in SaCoaA that strongly binds ATP by using a classical P loop architecture coupled with specific interactions with the adenine moiety. The PaCoaA*Pan binary complex explains the resistance of bacteria possessing this isoform to the pantothenamide antibiotics, and the similarity between SaCoaA and human pantothenate kinase 2 explains the molecular basis for the development of the neurodegenerative phenotype in three mutations in the human protein.

About this Structure

2F9T is a Single protein structure of sequence from Pseudomonas aeruginosa pao1. Full crystallographic information is available from OCA.

Reference

Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties., Hong BS, Yun MK, Zhang YM, Chohnan S, Rock CO, White SW, Jackowski S, Park HW, Leonardi R, Structure. 2006 Aug;14(8):1251-61. PMID:16905099 Page seeded by OCA on Sun May 4 03:38:28 2008

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