2f9u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2f9u.gif|left|200px]]
[[Image:2f9u.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2f9u |SIZE=350|CAPTION= <scene name='initialview01'>2f9u</scene>, resolution 2.60&Aring;
+
The line below this paragraph, containing "STRUCTURE_2f9u", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=5NH:1,1-DIMETHYLETHYL+[1-CYCLOHEXYL-2-[3-[[[1-[2-[[2-[[2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO]-2-OXOETHYL]AMINO]-1,2-DIOXOETHYL]PENTYL]AMINO]CARBONYL]-2-AZABICYCLO[2.2.1]HEPTAN-2-YL]-2-OXOETHYL]CARBAMATE'>5NH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= NS3 protease domain ( residues 1027-1207 of the polyprotein). ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2f9u| PDB=2f9u | SCENE= }}
-
|RELATEDENTRY=[[1a1r|1A1R]], [[1jxp|1JXP]], [[2a4g|2A4G]], [[2a4q|2A4Q]], [[2a4r|2A4R]], [[1n1l|1N1L]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f9u OCA], [http://www.ebi.ac.uk/pdbsum/2f9u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f9u RCSB]</span>
+
-
}}
+
'''HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane'''
'''HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane'''
Line 32: Line 29:
[[Category: Venkatraman, S.]]
[[Category: Venkatraman, S.]]
[[Category: Wu, W.]]
[[Category: Wu, W.]]
-
[[Category: hcv]]
+
[[Category: Hcv]]
-
[[Category: hepatitis c protease]]
+
[[Category: Hepatitis c protease]]
-
[[Category: ketoamide inhibitor]]
+
[[Category: Ketoamide inhibitor]]
-
[[Category: ns3 protease]]
+
[[Category: Ns3 protease]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:38:29 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:59:51 2008''
+

Revision as of 00:38, 4 May 2008

Image:2f9u.gif

Template:STRUCTURE 2f9u

HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane


Overview

Prolonged hepatitis C infection is the leading cause for cirrhosis of the liver and hepatocellular carcinoma. The etiological agent HCV virus codes a single polyprotein of approximately 3000 amino acids that is processed with the help of a serine protease NS3A to produce structural and non-structural proteins required for viral replication. Inhibition of NS3 protease can potentially be used to develop drugs for treatment of HCV infections. Herein, we report the development of a series of novel NS3 serine protease inhibitors derived from 2-aza-bicyclo[2.2.1]-heptane carboxylic acid with potential therapeutic use for treatment of HCV infections.

About this Structure

2F9U is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid., Venkatraman S, Njoroge FG, Wu W, Girijavallabhan V, Prongay AJ, Butkiewicz N, Pichardo J, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1628-32. Epub 2006 Jan 18. PMID:16413182 Page seeded by OCA on Sun May 4 03:38:29 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f9u"
Personal tools