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2fau

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[[Image:2fau.gif|left|200px]]
[[Image:2fau.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2fau |SIZE=350|CAPTION= <scene name='initialview01'>2fau</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_2fau", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= VPS26A, VPS26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2fau| PDB=2fau | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fau OCA], [http://www.ebi.ac.uk/pdbsum/2fau PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fau RCSB]</span>
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}}
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'''Crystal structure of human vps26'''
'''Crystal structure of human vps26'''
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[[Category: Rojas, R.]]
[[Category: Rojas, R.]]
[[Category: Shi, H.]]
[[Category: Shi, H.]]
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[[Category: arrestin]]
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[[Category: Arrestin]]
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[[Category: retromer]]
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[[Category: Retromer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:40:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:00:11 2008''
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Revision as of 00:40, 4 May 2008

Image:2fau.gif

Template:STRUCTURE 2fau

Crystal structure of human vps26


Overview

The mammalian retromer complex consists of SNX1, SNX2, Vps26, Vps29 and Vps35, and retrieves lysosomal enzyme receptors from endosomes to the trans-Golgi network. The structure of human Vps26A at 2.1-A resolution reveals two curved beta-sandwich domains connected by a polar core and a flexible linker. Vps26 has an unpredicted structural relationship to arrestins. The Vps35-binding site on Vps26 maps to a mobile loop spanning residues 235-246, near the tip of the C-terminal domain. The loop is phylogenetically conserved and provides a mechanism for Vps26 integration into the complex that leaves the rest of the structure free for engagements with membranes and for conformational changes. Hydrophobic residues and a glycine in this loop are required for integration into the retromer complex and endosomal localization of human Vps26, and for the function of yeast Vps26 in carboxypeptidase Y sorting.

About this Structure

2FAU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain., Shi H, Rojas R, Bonifacino JS, Hurley JH, Nat Struct Mol Biol. 2006 Jun;13(6):540-8. Epub 2006 May 28. PMID:16732284 Page seeded by OCA on Sun May 4 03:40:17 2008

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