2fd6

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[[Image:2fd6.gif|left|200px]]
[[Image:2fd6.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2fd6 |SIZE=350|CAPTION= <scene name='initialview01'>2fd6</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2fd6", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ETX:2-ETHOXYETHANOL'>ETX</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2fd6| PDB=2fd6 | SCENE= }}
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|RELATEDENTRY=[[2fat|2fat]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd6 OCA], [http://www.ebi.ac.uk/pdbsum/2fd6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fd6 RCSB]</span>
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}}
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'''Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A'''
'''Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A'''
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[[Category: Huang, M.]]
[[Category: Huang, M.]]
[[Category: Li, Y.]]
[[Category: Li, Y.]]
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[[Category: atf]]
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[[Category: Atf]]
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[[Category: atn-615 antibody]]
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[[Category: Atn-615 antibody]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: fab]]
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[[Category: Fab]]
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[[Category: ternary complex]]
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[[Category: Ternary complex]]
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[[Category: upar]]
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[[Category: Upar]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:45:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:01:08 2008''
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Revision as of 00:45, 4 May 2008

Image:2fd6.gif

Template:STRUCTURE 2fd6

Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A


Overview

The urokinase plasminogen activator binds to its cellular receptor with high affinity and initiates signaling cascades that are implicated in pathological processes including tumor growth, metastasis, and inflammation. We report the crystal structure at 1.9 angstroms of the urokinase receptor complexed with the urokinase amino-terminal fragment and an antibody against the receptor. The three domains of urokinase receptor form a concave shape with a central cone-shaped cavity where the urokinase fragment inserts. The structure provides insight into the flexibility of the urokinase receptor that enables its interaction with a wide variety of ligands and a basis for the design of urokinase-urokinase receptor antagonists.

About this Structure

2FD6 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of human urokinase plasminogen activator in complex with its receptor., Huai Q, Mazar AP, Kuo A, Parry GC, Shaw DE, Callahan J, Li Y, Yuan C, Bian C, Chen L, Furie B, Furie BC, Cines DB, Huang M, Science. 2006 Feb 3;311(5761):656-9. PMID:16456079 Page seeded by OCA on Sun May 4 03:45:10 2008

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OCA

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