2ffl

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[[Image:2ffl.gif|left|200px]]
[[Image:2ffl.gif|left|200px]]
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{{Structure
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|PDB= 2ffl |SIZE=350|CAPTION= <scene name='initialview01'>2ffl</scene>, resolution 3.33&Aring;
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The line below this paragraph, containing "STRUCTURE_2ffl", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span>
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{{STRUCTURE_2ffl| PDB=2ffl | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ffl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffl OCA], [http://www.ebi.ac.uk/pdbsum/2ffl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ffl RCSB]</span>
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'''Crystal Structure of Dicer from Giardia intestinalis'''
'''Crystal Structure of Dicer from Giardia intestinalis'''
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[[Category: Doudna, J A.]]
[[Category: Doudna, J A.]]
[[Category: MacRae, I J.]]
[[Category: MacRae, I J.]]
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[[Category: paz domain]]
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[[Category: Paz domain]]
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[[Category: rna interference]]
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[[Category: Rna interference]]
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[[Category: rnai]]
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[[Category: Rnai]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:50:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:02:09 2008''
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Revision as of 00:50, 4 May 2008

Image:2ffl.gif

Template:STRUCTURE 2ffl

Crystal Structure of Dicer from Giardia intestinalis


Overview

The specialized ribonuclease Dicer initiates RNA interference by cleaving double-stranded RNA (dsRNA) substrates into small fragments about 25 nucleotides in length. In the crystal structure of an intact Dicer enzyme, the PAZ domain, a module that binds the end of dsRNA, is separated from the two catalytic ribonuclease III (RNase III) domains by a flat, positively charged surface. The 65 angstrom distance between the PAZ and RNase III domains matches the length spanned by 25 base pairs of RNA. Thus, Dicer itself is a molecular ruler that recognizes dsRNA and cleaves a specified distance from the helical end.

About this Structure

2FFL is a Single protein structure of sequence from Giardia intestinalis. Full crystallographic information is available from OCA.

Reference

Structural basis for double-stranded RNA processing by Dicer., Macrae IJ, Zhou K, Li F, Repic A, Brooks AN, Cande WZ, Adams PD, Doudna JA, Science. 2006 Jan 13;311(5758):195-8. PMID:16410517 Page seeded by OCA on Sun May 4 03:50:20 2008

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