2fg4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2fg4.gif|left|200px]]
[[Image:2fg4.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2fg4 |SIZE=350|CAPTION= <scene name='initialview01'>2fg4</scene>, resolution 2.10&Aring;
+
The line below this paragraph, containing "STRUCTURE_2fg4", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= FTL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2fg4| PDB=2fg4 | SCENE= }}
-
|RELATEDENTRY=[[2ffx|2FFX]], [[2fg8|2FG8]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fg4 OCA], [http://www.ebi.ac.uk/pdbsum/2fg4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fg4 RCSB]</span>
+
-
}}
+
'''Structure of Human Ferritin L Chain'''
'''Structure of Human Ferritin L Chain'''
Line 34: Line 31:
[[Category: Ruble, J.]]
[[Category: Ruble, J.]]
[[Category: Wang, Z.]]
[[Category: Wang, Z.]]
-
[[Category: human light chain ferritin]]
+
[[Category: Human light chain ferritin]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:51:12 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:02:19 2008''
+

Revision as of 00:51, 4 May 2008

Image:2fg4.gif

Template:STRUCTURE 2fg4

Structure of Human Ferritin L Chain


Contents

Overview

Ferritin is the major iron-storage protein present in all cells. It generally contains 24 subunits, with different ratios of heavy chain (H) to light chain (L), in the shape of a hollow sphere hosting up to 4500 ferric Fe atoms inside. H-rich ferritins catalyse the oxidation of iron(II), while L-rich ferritins promote the nucleation and storage of iron(III). Several X-ray structures have been determined, including those of L-chain ferritins from horse spleen (HoSF), recombinant L-chain ferritins from horse (HoLF), mouse (MoLF) and bullfrog (BfLF) as well as recombinant human H-chain ferritin (HuHF). Here, structures have been determined of two crystal forms of recombinant human L-chain ferritin (HuLF) obtained from native and perdeuterated proteins. The structures show a cluster of acidic residues at the ferrihydrite nucleation site and at the iron channel along the threefold axis. An ordered Cd2+ structure is observed within the iron channel, offering further insight into the route and mechanism of iron transport into the capsid. The loop between helices D and E, which is disordered in many other L-chain structures, is clearly visible in these two structures. The crystals generated from perdeuterated HuLF will be used for neutron diffraction studies.

Disease

Known disease associated with this structure: Basal ganglia disease, adult-onset OMIM:[134790], Hyperferritinemia-cataract syndrome OMIM:[134790]

About this Structure

2FG4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human ferritin L chain., Wang Z, Li C, Ellenburg M, Soistman E, Ruble J, Wright B, Ho JX, Carter DC, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):800-6. Epub 2006, Jun 20. PMID:16790936 Page seeded by OCA on Sun May 4 03:51:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fg4"
Personal tools