2fhy

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[[Image:2fhy.gif|left|200px]]
[[Image:2fhy.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2fhy |SIZE=350|CAPTION= <scene name='initialview01'>2fhy</scene>, resolution 2.95&Aring;
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The line below this paragraph, containing "STRUCTURE_2fhy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A37:2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE'>A37</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2fhy| PDB=2fhy | SCENE= }}
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|RELATEDENTRY=[[2fie|2FIE]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fhy OCA], [http://www.ebi.ac.uk/pdbsum/2fhy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fhy RCSB]</span>
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}}
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'''Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor'''
'''Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Abad-Zapatero, C.]]
[[Category: Abad-Zapatero, C.]]
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[[Category: allosteric inhibitors human fbpase]]
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[[Category: Allosteric inhibitors human fbpase]]
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[[Category: benzoxazole]]
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[[Category: Benzoxazole]]
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[[Category: intersubunit allosteric inhibition of human fpbase]]
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[[Category: Intersubunit allosteric inhibition of human fpbase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:55:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:03:04 2008''
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Revision as of 00:55, 4 May 2008

Image:2fhy.gif

Template:STRUCTURE 2fhy

Structure of human liver FPBase complexed with a novel benzoxazole as allosteric inhibitor


Overview

We have identified benzoxazole benzenesulfonamide 1 as a novel allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1). X-ray crystallographic and biological studies of 1 indicate a distinct binding mode that recapitulates features of several previously reported FBPase-1 inhibitor classes.

About this Structure

2FHY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode., von Geldern TW, Lai C, Gum RJ, Daly M, Sun C, Fry EH, Abad-Zapatero C, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1811-5. Epub 2006 Jan 25. PMID:16442285 Page seeded by OCA on Sun May 4 03:55:10 2008

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OCA

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