2je1
From Proteopedia
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Revision as of 20:48, 12 November 2007
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THE CRYSTAL STRUCTURE OF THE TUMOR SUPRESSOR PROTEIN PP32 (ANP32A):STRUCTURAL INSIGHTS INTO THE ANP32 FAMILY OF PROTEINS
Overview
The tumor suppressor protein pp32 is highly overexpressed in many cancers, of the breast and prostate, and has also been implicated in the, neurodegenerative disease spinocerebellar ataxias type 1 (SCA1). Pp32 is a, multifunctional protein that is involved in the regulation of, transcription, apoptosis, phosphorylation, and cell cycle progression, the, latter through its association with the hyperphosphorylated form of the, retinoblastoma tumor suppressor. We have determined the structure of an, N-terminal pp32 fragment comprising a capped leucine-rich repeat (LRR), domain, which provides insight into the structural and biochemical, properties of the pp32 (Anp32) family of proteins.
About this Structure
2JE1 is a Single protein structure of sequence from Homo sapiens with GOL as ligand. Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins., Huyton T, Wolberger C, Protein Sci. 2007 Jul;16(7):1308-15. Epub 2007 Jun 13. PMID:17567741
Page seeded by OCA on Mon Nov 12 22:54:40 2007
Categories: Homo sapiens | Single protein | Huyton, T. | Wolberger, C. | GOL | Anp32 | Lanp | Leucine-rich repeat | Lrr | Nuclear protein | Phapi | Phosphorylation
