2fk9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2fk9.gif|left|200px]]
[[Image:2fk9.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2fk9 |SIZE=350|CAPTION= <scene name='initialview01'>2fk9</scene>, resolution 1.75&Aring;
+
The line below this paragraph, containing "STRUCTURE_2fk9", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= PRKCH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2fk9| PDB=2fk9 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fk9 OCA], [http://www.ebi.ac.uk/pdbsum/2fk9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fk9 RCSB]</span>
+
-
}}
+
'''Human protein kinase C, eta'''
'''Human protein kinase C, eta'''
Line 41: Line 38:
[[Category: Walker, J R.]]
[[Category: Walker, J R.]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
-
[[Category: atp-binding]]
+
[[Category: Atp-binding]]
-
[[Category: diacylglycerol binding]]
+
[[Category: Diacylglycerol binding]]
-
[[Category: kinase]]
+
[[Category: Kinase]]
-
[[Category: metal-binding]]
+
[[Category: Metal-binding]]
-
[[Category: nucleotide-binding]]
+
[[Category: Nucleotide-binding]]
-
[[Category: serine/threonine-protein kinase]]
+
[[Category: Serine/threonine-protein kinase]]
-
[[Category: sgc]]
+
[[Category: Sgc]]
-
[[Category: structural genomic]]
+
[[Category: Structural genomic]]
-
[[Category: structural genomics consortium]]
+
[[Category: Structural genomics consortium]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:59:41 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:04:00 2008''
+

Revision as of 00:59, 4 May 2008

Image:2fk9.gif

Template:STRUCTURE 2fk9

Human protein kinase C, eta


Contents

Overview

Protein kinase C eta (PKCeta) is one of several PKC isoforms found in humans. It is a novel PKC isoform in that it is activated by diacylglycerol and anionic phospholipids but not calcium. The crystal structure of the PKCeta-C2 domain, which is thought to mediate anionic phospholipid sensing in the protein, was determined at 1.75 A resolution. The structure is similar to that of the PKC epsilon C2 domain but with significant variations at the putative lipid-binding site. Two serine residues within PKC eta were identified in vitro as potential autophosphorylation sites. In the unphosphorylated structure both serines line the putative lipid-binding site and may therefore play a role in the lipid-regulation of the kinase.

Disease

Known disease associated with this structure: Cerebral infarction, susceptibility to OMIM:[605437]

About this Structure

2FK9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites., Littler DR, Walker JR, She YM, Finerty PJ Jr, Newman EM, Dhe-Paganon S, Biochem Biophys Res Commun. 2006 Nov 3;349(4):1182-9. Epub 2006 Sep 5. PMID:16973127 Page seeded by OCA on Sun May 4 03:59:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fk9"
Personal tools