2fmm

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[[Image:2fmm.gif|left|200px]]
[[Image:2fmm.gif|left|200px]]
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{{Structure
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|PDB= 2fmm |SIZE=350|CAPTION= <scene name='initialview01'>2fmm</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_2fmm", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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|GENE= EMSY, C11orf30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CBX1, CBX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2fmm| PDB=2fmm | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fmm OCA], [http://www.ebi.ac.uk/pdbsum/2fmm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fmm RCSB]</span>
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'''Crystal Structure of EMSY-HP1 complex'''
'''Crystal Structure of EMSY-HP1 complex'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Huang, Y.]]
[[Category: Huang, Y.]]
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[[Category: chromo shadow domain]]
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[[Category: Chromo shadow domain]]
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[[Category: emsy protein]]
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[[Category: Emsy protein]]
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[[Category: ent domain]]
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[[Category: Ent domain]]
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[[Category: heterochromatin protein 1]]
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[[Category: Heterochromatin protein 1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:04:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:04:55 2008''
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Revision as of 01:04, 4 May 2008

Image:2fmm.gif

Template:STRUCTURE 2fmm

Crystal Structure of EMSY-HP1 complex


Overview

Heterochromatin protein-1 (HP1) plays an essential role in both the assembly of higher-order chromatin structure and epigenetic inheritance. The C-terminal chromo shadow domain (CSD) of HP1 is responsible for homodimerization and interaction with a number of chromatin-associated nonhistone proteins, including EMSY, which is a BRCA2-interacting protein that has been implicated in the development of breast and ovarian cancer. We have determined the crystal structure of the HP1beta CSD in complex with the N-terminal domain of EMSY at 1.8 A resolution. Surprisingly, the structure reveals that EMSY is bound by two HP1 CSD homodimers, and the binding sequences differ from the consensus HP1 binding motif PXVXL. This structural information expands our understanding of HP1 binding specificity and provides insights into interactions between HP1 homodimers that are likely to be important for heterochromatin formation.

About this Structure

2FMM is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding., Huang Y, Myers MP, Xu RM, Structure. 2006 Apr;14(4):703-12. PMID:16615912 Page seeded by OCA on Sun May 4 04:04:27 2008

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OCA

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