2fny

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[[Image:2fny.gif|left|200px]]
[[Image:2fny.gif|left|200px]]
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{{Structure
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|PDB= 2fny |SIZE=350|CAPTION= <scene name='initialview01'>2fny</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2fny", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ESY:BENZYL+N-[(BENZYLOXY)CARBONYL]-D-ALANYL-N~6~-[(2S,3S,4S)-3-FORMYL-2-HYDROXY-4-METHYLHEXANOYL]-L-LYSINATE'>ESY</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2fny| PDB=2fny | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fny OCA], [http://www.ebi.ac.uk/pdbsum/2fny PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fny RCSB]</span>
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'''Homobelactosin C bound to the yeast 20S proteasome'''
'''Homobelactosin C bound to the yeast 20S proteasome'''
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Groll, M.]]
[[Category: Groll, M.]]
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[[Category: beta sandwich structure flanked by helice]]
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[[Category: Beta sandwich structure flanked by helice]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:07:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:05:21 2008''
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Revision as of 01:07, 4 May 2008

Image:2fny.gif

Template:STRUCTURE 2fny

Homobelactosin C bound to the yeast 20S proteasome


Overview

Most class I MHC ligands are generated from the vast majority of cellular proteins by proteolysis within the ubiquitin-proteasome pathway and are presented on the cell surface by MHC class I molecules. Here, we present the crystallographic analysis of yeast 20S proteasome in complex with the inhibitor homobelactosin C. The structure reveals a unique inhibitor-binding mode and provides information about the composition of proteasomal primed substrate-binding sites. IFN-gamma inducible substitution of proteasomal constitutive subunits by immunosubunits modulates characteristics of generated peptides, thus producing fragments with higher preference for binding to MHC class I molecules. The structural data for the proteasome:homobelactosin C complex provide an explanation for involvement of immunosubunits in antigen generation and open perspectives for rational design of ligands, inhibiting exclusively constitutive proteasomes or immunoproteasomes.

About this Structure

2FNY is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Inhibitor-binding mode of homobelactosin C to proteasomes: new insights into class I MHC ligand generation., Groll M, Larionov OV, Huber R, de Meijere A, Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4576-9. Epub 2006 Mar 13. PMID:16537370 Page seeded by OCA on Sun May 4 04:07:01 2008

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