2foq

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[[Image:2foq.gif|left|200px]]
[[Image:2foq.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2foq |SIZE=350|CAPTION= <scene name='initialview01'>2foq</scene>, resolution 1.25&Aring;
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The line below this paragraph, containing "STRUCTURE_2foq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=B15:[2,2&#39;-({4-[({2-[4-(AMINOSULFONYL)PHENYL]ETHYL}AMINO)CARBONYL]BENZYL}IMINO)DIACETATO(2-)-KAPPAO]COPPER'>B15</scene>, <scene name='pdbligand=CMH:S-(METHYLMERCURY)-L-CYSTEINE'>CMH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2foq| PDB=2foq | SCENE= }}
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|RELATEDENTRY=[[2cba|2CBA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2foq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2foq OCA], [http://www.ebi.ac.uk/pdbsum/2foq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2foq RCSB]</span>
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}}
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'''Human Carbonic Anhydrase II complexed with two-prong inhibitors'''
'''Human Carbonic Anhydrase II complexed with two-prong inhibitors'''
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[[Category: Christianson, D W.]]
[[Category: Christianson, D W.]]
[[Category: Jude, K M.]]
[[Category: Jude, K M.]]
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[[Category: copper]]
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[[Category: Copper]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: zinc]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:08:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:05:43 2008''
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Revision as of 01:08, 4 May 2008

Image:2foq.gif

Template:STRUCTURE 2foq

Human Carbonic Anhydrase II complexed with two-prong inhibitors


Contents

Overview

The atomic-resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors are reported. Each inhibitor contains a benzenesulfonamide prong and a cupric iminodiacetate (IDA-Cu(2+)) prong separated by linkers of different lengths and compositions. The ionized NH(-) group of each benzenesulfonamide coordinates to the active site Zn(2+) ion; the IDA-Cu(2+) prong of the tightest-binding inhibitor, BR30, binds to H64 of CAII and H200 of CAI. This work provides the first evidence verifying the structural basis of nanomolar affinity measured for two-prong inhibitors targeting the carbonic anhydrases.

Disease

Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[611492]

About this Structure

2FOQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity., Jude KM, Banerjee AL, Haldar MK, Manokaran S, Roy B, Mallik S, Srivastava DK, Christianson DW, J Am Chem Soc. 2006 Mar 8;128(9):3011-8. PMID:16506782 Page seeded by OCA on Sun May 4 04:08:46 2008

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OCA

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