2fos

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2fos.gif|left|200px]]
[[Image:2fos.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2fos |SIZE=350|CAPTION= <scene name='initialview01'>2fos</scene>, resolution 1.1&Aring;
+
The line below this paragraph, containing "STRUCTURE_2fos", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=B17:{1-[4-(AMINOSULFONYL)PHENYL]-11-[(CARBOXY-KAPPAO)METHYL]-1-OXO-5,8-DIOXA-2,11-DIAZATRIDECAN-13-OATO(2-)-KAPPAO~13~}COPPER'>B17</scene>, <scene name='pdbligand=CMH:S-(METHYLMERCURY)-L-CYSTEINE'>CMH</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2fos| PDB=2fos | SCENE= }}
-
|RELATEDENTRY=[[2cba|2CBA]], [[2foq|2FOQ]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fos OCA], [http://www.ebi.ac.uk/pdbsum/2fos PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fos RCSB]</span>
+
-
}}
+
'''Human Carbonic Anhydrase II complexed with two-prong inhibitors'''
'''Human Carbonic Anhydrase II complexed with two-prong inhibitors'''
Line 31: Line 28:
[[Category: Christianson, D W.]]
[[Category: Christianson, D W.]]
[[Category: Jude, K M.]]
[[Category: Jude, K M.]]
-
[[Category: copper]]
+
[[Category: Copper]]
-
[[Category: inhibitor]]
+
[[Category: Inhibitor]]
-
[[Category: lyase]]
+
[[Category: Lyase]]
-
[[Category: zinc]]
+
[[Category: Zinc]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:08:50 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:05:46 2008''
+

Revision as of 01:08, 4 May 2008

Image:2fos.gif

Template:STRUCTURE 2fos

Human Carbonic Anhydrase II complexed with two-prong inhibitors


Contents

Overview

The atomic-resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors are reported. Each inhibitor contains a benzenesulfonamide prong and a cupric iminodiacetate (IDA-Cu(2+)) prong separated by linkers of different lengths and compositions. The ionized NH(-) group of each benzenesulfonamide coordinates to the active site Zn(2+) ion; the IDA-Cu(2+) prong of the tightest-binding inhibitor, BR30, binds to H64 of CAII and H200 of CAI. This work provides the first evidence verifying the structural basis of nanomolar affinity measured for two-prong inhibitors targeting the carbonic anhydrases.

Disease

Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[611492]

About this Structure

2FOS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity., Jude KM, Banerjee AL, Haldar MK, Manokaran S, Roy B, Mallik S, Srivastava DK, Christianson DW, J Am Chem Soc. 2006 Mar 8;128(9):3011-8. PMID:16506782 Page seeded by OCA on Sun May 4 04:08:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fos"
Personal tools