2fqn
From Proteopedia
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'''Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site''' | '''Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FQN OCA]. | |
==Reference== | ==Reference== | ||
Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site., Kondo J, Urzhumtsev A, Westhof E, Nucleic Acids Res. 2006 Feb 1;34(2):676-85. Print 2006. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16452297 16452297] | Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site., Kondo J, Urzhumtsev A, Westhof E, Nucleic Acids Res. 2006 Feb 1;34(2):676-85. Print 2006. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16452297 16452297] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Kondo, J.]] | [[Category: Kondo, J.]] | ||
[[Category: Urzhumtsev, A.]] | [[Category: Urzhumtsev, A.]] | ||
[[Category: Westhof, E.]] | [[Category: Westhof, E.]] | ||
| - | [[Category: | + | [[Category: A site]] |
| - | [[Category: | + | [[Category: Decoding site]] |
| - | [[Category: | + | [[Category: Homo sapiens cytoplasm]] |
| - | [[Category: | + | [[Category: Rna duplex]] |
| - | [[Category: | + | [[Category: Rrna]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:12:20 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:12, 4 May 2008
Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site
Overview
The decoding A site of the small ribosomal subunit is an RNA molecular switch, which monitors codon-anticodon interactions to guarantee translation fidelity. We have solved the crystal structure of an RNA fragment containing two Homo sapiens cytoplasmic A sites. Each of the two A sites presents a different conformational state. In one state, adenines A1492 and A1493 are fully bulged-out with C1409 forming a wobble-like pair to A1491. In the second state, adenines A1492 and A1493 form non-Watson-Crick pairs with C1409 and G1408, respectively while A1491 bulges out. The first state of the eukaryotic A site is, thus, basically the same as in the bacterial A site with bulging A1492 and A1493. It is the state used for recognition of the codon/anticodon complex. On the contrary, the second state of the H.sapiens cytoplasmic A site is drastically different from any of those observed for the bacterial A site without bulging A1492 and A1493.
About this Structure
Full crystallographic information is available from OCA.
Reference
Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site., Kondo J, Urzhumtsev A, Westhof E, Nucleic Acids Res. 2006 Feb 1;34(2):676-85. Print 2006. PMID:16452297 Page seeded by OCA on Sun May 4 04:12:20 2008
