2ftk

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[[Image:2ftk.gif|left|200px]]
[[Image:2ftk.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2ftk |SIZE=350|CAPTION= <scene name='initialview01'>2ftk</scene>, resolution 3.05&Aring;
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The line below this paragraph, containing "STRUCTURE_2ftk", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BFD:ASPARTATE+BERYLLIUM+TRIFLUORIDE'>BFD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= spo0B, spo0D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis]), spo0F ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
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-->
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|DOMAIN=
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{{STRUCTURE_2ftk| PDB=2ftk | SCENE= }}
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|RELATEDENTRY=[[1f51|1F51]], [[1ixm|1IXM]], [[1srr|1SRR]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ftk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ftk OCA], [http://www.ebi.ac.uk/pdbsum/2ftk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ftk RCSB]</span>
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}}
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'''berylloflouride Spo0F complex with Spo0B'''
'''berylloflouride Spo0F complex with Spo0B'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Varughese, K I.]]
[[Category: Varughese, K I.]]
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[[Category: spo0b phosphorelay]]
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[[Category: Spo0b phosphorelay]]
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[[Category: spo0f]]
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[[Category: Spo0f]]
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[[Category: sporulation]]
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[[Category: Sporulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:17:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:07:28 2008''
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Revision as of 01:17, 4 May 2008

Image:2ftk.gif

Template:STRUCTURE 2ftk

berylloflouride Spo0F complex with Spo0B


Overview

A number of regulatory circuits in biological systems function through the exchange of phosphoryl groups from one protein to another. Spo0F and Spo0B are components of a phosphorelay that control sporulation in the bacterium Bacillus subtilis through the exchange of a phosphoryl group. Using beryllofluoride as a mimic for phosphorylation, we trapped the interaction of the phosphorylated Spo0F with Spo0B in the crystal lattice. The transition state of phosphoryl transfer continues to be a highly debated issue, as to whether it is associative or dissociative in nature. The geometry of Spo0F binding to Spo0B favors an associative mechanism for phosphoryl transfer. In order to visualize the autophosphorylation of the histidine kinase, KinA, and the subsequent phosphoryl transfer to Spo0F, we generated in silico models representing these reaction steps.

About this Structure

2FTK is a Protein complex structure of sequences from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

The crystal structure of beryllofluoride Spo0F in complex with the phosphotransferase Spo0B represents a phosphotransfer pretransition state., Varughese KI, Tsigelny I, Zhao H, J Bacteriol. 2006 Jul;188(13):4970-7. PMID:16788205 Page seeded by OCA on Sun May 4 04:17:43 2008

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OCA

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