2fum

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2fum.gif|left|200px]]
[[Image:2fum.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2fum |SIZE=350|CAPTION= <scene name='initialview01'>2fum</scene>, resolution 2.89&Aring;
+
The line below this paragraph, containing "STRUCTURE_2fum", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MIX:1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE'>MIX</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= pknB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2fum| PDB=2fum | SCENE= }}
-
|RELATEDENTRY=[[1o6y|1O6Y]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fum OCA], [http://www.ebi.ac.uk/pdbsum/2fum PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fum RCSB]</span>
+
-
}}
+
'''Catalytic domain of protein kinase PknB from Mycobacterium tuberculosis in complex with mitoxantrone'''
'''Catalytic domain of protein kinase PknB from Mycobacterium tuberculosis in complex with mitoxantrone'''
Line 28: Line 25:
[[Category: Alzari, P M.]]
[[Category: Alzari, P M.]]
[[Category: Wehenkel, A.]]
[[Category: Wehenkel, A.]]
-
[[Category: protein kinase-inhibitor complex]]
+
[[Category: Protein kinase-inhibitor complex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:19:45 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:07:55 2008''
+

Revision as of 01:19, 4 May 2008

Image:2fum.gif

Template:STRUCTURE 2fum

Catalytic domain of protein kinase PknB from Mycobacterium tuberculosis in complex with mitoxantrone


Overview

Mycobacterium tuberculosis PknB is an essential receptor-like protein kinase involved in cell growth control. Here, we demonstrate that mitoxantrone, an anthraquinone derivative used in cancer therapy, is a PknB inhibitor capable of preventing mycobacterial growth. The structure of the complex reveals that mitoxantrone partially occupies the adenine-binding pocket in PknB, providing a framework for the design of compounds with potential therapeutic applications. PknB crystallizes as a 'back-to-back' homodimer identical to those observed in other structures of PknB in complex with ATP analogs. This organization resembles that of the RNA-dependent protein kinase PKR, suggesting a mechanism for kinase activation in mycobacteria.

About this Structure

2FUM is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria., Wehenkel A, Fernandez P, Bellinzoni M, Catherinot V, Barilone N, Labesse G, Jackson M, Alzari PM, FEBS Lett. 2006 May 29;580(13):3018-22. Epub 2006 Apr 27. PMID:16674948 Page seeded by OCA on Sun May 4 04:19:45 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fum"
Personal tools