2fv4

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[[Image:2fv4.gif|left|200px]]
[[Image:2fv4.gif|left|200px]]
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{{Structure
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|PDB= 2fv4 |SIZE=350|CAPTION= <scene name='initialview01'>2fv4</scene>
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The line below this paragraph, containing "STRUCTURE_2fv4", creates the "Structure Box" on the page.
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|GENE= YER018C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), YMR117C, YM9718.16C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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{{STRUCTURE_2fv4| PDB=2fv4 | SCENE= }}
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|RELATEDENTRY=[[2ftx|2FTX]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fv4 OCA], [http://www.ebi.ac.uk/pdbsum/2fv4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fv4 RCSB]</span>
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'''NMR solution structure of the yeast kinetochore Spc24/Spc25 globular domain'''
'''NMR solution structure of the yeast kinetochore Spc24/Spc25 globular domain'''
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[[Category: Chou, J J.]]
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[[Category: Schnell, J R.]]
[[Category: Schnell, J R.]]
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[[Category: alpha-beta]]
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[[Category: Alpha-beta]]
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[[Category: coiled-coil]]
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[[Category: Coiled-coil]]
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[[Category: complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:20:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:08:04 2008''
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Revision as of 01:20, 4 May 2008

Image:2fv4.gif

Template:STRUCTURE 2fv4

NMR solution structure of the yeast kinetochore Spc24/Spc25 globular domain


Overview

The Ndc80 complex, a kinetochore component conserved from yeast to humans, is essential for proper chromosome alignment and segregation during mitosis. It is an approximately 570 A long, rod-shaped assembly of four proteins--Ndc80p (Hec1), Nuf2p, Spc24p, and Spc25p--with globular regions at either end of a central shaft. The complex bridges from the centromere-proximal inner kinetochore layer at its Spc24/Spc25 globular end to the microtubule binding outer kinetochore layer at its Ndc80/Nuf2 globular end. We report the atomic structures of the Spc24/Spc25 globular domain, determined both by X-ray crystallography at 1.9 A resolution and by NMR. Spc24 and Spc25 fold tightly together into a single globular entity with pseudo-2-fold symmetry. Conserved residues line a common hydrophobic core and the bottom of a cleft, indicating that the functional orthologs from other eukaryotes will have the same structure and suggesting a docking site for components of the inner kinetochore.

About this Structure

2FV4 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain., Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SC, Structure. 2006 Jun;14(6):1003-9. PMID:16765893 Page seeded by OCA on Sun May 4 04:20:28 2008

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