2fwm

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[[Image:2fwm.gif|left|200px]]
[[Image:2fwm.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2fwm |SIZE=350|CAPTION= <scene name='initialview01'>2fwm</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2fwm", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/2,3-dihydro-2,3-dihydroxybenzoate_dehydrogenase 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.28 1.3.1.28] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= entA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_2fwm| PDB=2fwm | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwm OCA], [http://www.ebi.ac.uk/pdbsum/2fwm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fwm RCSB]</span>
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'''Crystal Structure of E. coli EntA, a 2,3-dihydrodihydroxy benzoate dehydrogenase'''
'''Crystal Structure of E. coli EntA, a 2,3-dihydrodihydroxy benzoate dehydrogenase'''
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[[Category: Duax, W L.]]
[[Category: Duax, W L.]]
[[Category: Gulick, A M.]]
[[Category: Gulick, A M.]]
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[[Category: chorismate metabolism]]
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[[Category: Chorismate metabolism]]
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[[Category: enterobactin]]
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[[Category: Enterobactin]]
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[[Category: rossman fold]]
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[[Category: Rossman fold]]
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[[Category: short-chain oxidoreductase]]
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[[Category: Short-chain oxidoreductase]]
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[[Category: tetramer]]
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[[Category: Tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:23:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:08:40 2008''
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Revision as of 01:23, 4 May 2008

Image:2fwm.gif

Template:STRUCTURE 2fwm

Crystal Structure of E. coli EntA, a 2,3-dihydrodihydroxy benzoate dehydrogenase


Overview

The Escherichia coli enterobactin synthetic cluster is composed of six proteins, EntA-EntF, that form the enterobactin molecule from three serine molecules and three molecules of 2,3-dihydroxybenzoic acid (DHB). EntC, EntB and EntA catalyze the three-step synthesis of DHB from chorismate. EntA is a member of the short-chain oxidoreductase (SCOR) family of proteins and catalyzes the final step in DHB synthesis, the NAD+-dependent oxidation of 2,3-dihydro-2,3-dihydroxybenzoic acid to DHB. The structure of EntA has been determined by multi-wavelength anomalous dispersion methods. Here, the 2.0 A crystal structure of EntA in the unliganded form is presented. Analysis of the structure in light of recent structural and bioinformatic analysis of other members of the SCOR family provides insight into the residues involved in cofactor and substrate binding.

About this Structure

2FWM is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Determination of the crystal structure of EntA, a 2,3-dihydro-2,3-dihydroxybenzoic acid dehydrogenase from Escherichia coli., Sundlov JA, Garringer JA, Carney JM, Reger AS, Drake EJ, Duax WL, Gulick AM, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):734-40. Epub 2006, Jun 20. PMID:16790929 Page seeded by OCA on Sun May 4 04:23:31 2008

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