2fxk

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[[Image:2fxk.gif|left|200px]]
[[Image:2fxk.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_2fxk", creates the "Structure Box" on the page.
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{{STRUCTURE_2fxk| PDB=2fxk | SCENE= }}
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|RELATEDENTRY=[[1zr5|1ZR5]], [[1zr3|1ZR3]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fxk OCA], [http://www.ebi.ac.uk/pdbsum/2fxk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fxk RCSB]</span>
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'''Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A)'''
'''Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A)'''
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==About this Structure==
==About this Structure==
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2FXK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1ZQ0. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXK OCA].
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2FXK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zq0 1zq0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXK OCA].
==Reference==
==Reference==
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[[Category: Pugieux, C.]]
[[Category: Pugieux, C.]]
[[Category: Scheffzek, K.]]
[[Category: Scheffzek, K.]]
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[[Category: a1pp]]
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[[Category: A1pp]]
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[[Category: chromatin]]
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[[Category: Chromatin]]
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[[Category: histone]]
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[[Category: Histone]]
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[[Category: macro-domain]]
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[[Category: Macro-domain]]
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[[Category: p-loop]]
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[[Category: P-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:25:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:09:03 2008''
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Revision as of 01:25, 4 May 2008

Image:2fxk.gif

Template:STRUCTURE 2fxk

Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A)


Overview

Histone macroH2A is a hallmark of mammalian heterochromatin. Here we show that human macroH2A1.1 binds the SirT1-metabolite O-acetyl-ADP-ribose (OAADPR) through its macro domain. The 1.6-A crystal structure and mutants reveal how the metabolite is recognized. Mutually exclusive exon use in the gene H2AFY produces macroH2A1.2, whose tissue distribution differs. MacroH2A1.2 shows only subtle structural changes but cannot bind nucleotides. Alternative splicing may thus regulate the binding of nicotinamide adenine dinucleotide (NAD) metabolites to chromatin.

About this Structure

2FXK is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1zq0. Full crystallographic information is available from OCA.

Reference

Splicing regulates NAD metabolite binding to histone macroH2A., Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG, Nat Struct Mol Biol. 2005 Jul;12(7):624-5. Epub 2005 Jun 19. PMID:15965484 Page seeded by OCA on Sun May 4 04:25:24 2008

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