2fys

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2fys.gif|left|200px]]
[[Image:2fys.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2fys |SIZE=350|CAPTION= <scene name='initialview01'>2fys</scene>, resolution 2.5&Aring;
+
The line below this paragraph, containing "STRUCTURE_2fys", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= Mapk1, Erk2, Mapk, Prkm1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2fys| PDB=2fys | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fys OCA], [http://www.ebi.ac.uk/pdbsum/2fys PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fys RCSB]</span>
+
-
}}
+
'''Crystal structure of Erk2 complex with KIM peptide derived from MKP3'''
'''Crystal structure of Erk2 complex with KIM peptide derived from MKP3'''
Line 30: Line 27:
[[Category: Zhang, Z Y.]]
[[Category: Zhang, Z Y.]]
[[Category: Zhou, B.]]
[[Category: Zhou, B.]]
-
[[Category: kim]]
+
[[Category: Kim]]
-
[[Category: map kinase]]
+
[[Category: Map kinase]]
-
[[Category: mkp3]]
+
[[Category: Mkp3]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:27:50 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:09:36 2008''
+

Revision as of 01:27, 4 May 2008

Image:2fys.gif

Template:STRUCTURE 2fys

Crystal structure of Erk2 complex with KIM peptide derived from MKP3


Overview

Mitogen-activated protein (MAP) kinases are central components of signal transduction pathways for cell proliferation, stress responses, and differentiation. Signaling efficiency and specificity are modulated in large part by docking interactions between individual MAP kinase and the kinase interaction motif (KIM), (R/K)(2-3)-X(1-6)-Phi(A)-X-Phi(B), in its cognate kinases, phosphatases, scaffolding proteins, and substrates. We have determined the crystal structure of extracellular signal-regulated protein kinase 2 bound to the KIM peptide from MAP kinase phosphatase 3, an extracellular signal-regulated protein kinase 2-specific phosphatase. The structure reveals that the KIM docking site, situated in a noncatalytic region opposite of the kinase catalytic pocket, is comprised of a highly acidic patch and a hydrophobic groove, which engage the basic and Phi(A)-X-Phi(B) residues, respectively, in the KIM sequence. The specific docking interactions observed in the structure consolidate all known biochemical data. In addition, structural comparison indicates that the KIM docking site is conserved in all MAP kinases. The results establish a structural model for understanding how MAP kinases interact with their regulators and substrates and provide new insights into how MAP kinase docking specificity can be achieved.

About this Structure

2FYS is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3., Liu S, Sun JP, Zhou B, Zhang ZY, Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5326-31. Epub 2006 Mar 27. PMID:16567630 Page seeded by OCA on Sun May 4 04:27:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2fys"
Personal tools