2npl
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(New page: 200px<br /> <applet load="2npl" size="450" color="white" frame="true" align="right" spinBox="true" caption="2npl" /> '''NMR Structure of CARD d2 Domain'''<br /> =...)
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Revision as of 20:54, 12 November 2007
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NMR Structure of CARD d2 Domain
Contents |
Overview
The coxsackievirus and adenovirus receptor (CAR) mediates entry of, coxsackievirus and adenovirus. CAR possesses an extracellular region that, is comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the, present work, the solution structure of CAR-D2, consisting of residues, 142-235 of human CAR, has been determined by NMR spectroscopy. CAR-D2 is, shown to be a beta-sandwich motif comprised of two beta-sheets, which are, stabilized by two disulfide bonds. The first beta-sheet is comprised of, beta-strands A, B, and E, and the second beta-sheet is comprised of, beta-strands C, F, and G. A relatively hydrophobic helix is found between, beta-strands C and E, which replaces beta-strand D of the classical c-type, immunoglobulin fold.
Disease
Known diseases associated with this structure: Adrenocortical tumor, somatic OMIM:[188830], Carney complex, type 1 OMIM:[188830], Myxoma, intracardiac OMIM:[188830], Pigmented adrenocortical disease, primary, 1 OMIM:[188830], Spastic paraplegia-7 OMIM:[602783], Thyroid carcinoma, papillary OMIM:[188830]
About this Structure
2NPL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the coxsackievirus and adenovirus receptor domain 2., Jiang S, Caffrey M, Protein Sci. 2007 Mar;16(3):539-42. PMID:17322536
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