2g31

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[[Image:2g31.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_2g31", creates the "Structure Box" on the page.
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|GENE= NOGO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g31 OCA], [http://www.ebi.ac.uk/pdbsum/2g31 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g31 RCSB]</span>
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'''Human Nogo-A functional domain: nogo60'''
'''Human Nogo-A functional domain: nogo60'''
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[[Category: Liu, J X.]]
[[Category: Liu, J X.]]
[[Category: Song, J X.]]
[[Category: Song, J X.]]
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[[Category: helix]]
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[[Category: Helix]]
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[[Category: nogo]]
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[[Category: Nogo]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:37:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:11:09 2008''
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Revision as of 01:37, 4 May 2008

Image:2g31.gif

Template:STRUCTURE 2g31

Human Nogo-A functional domain: nogo60


Overview

The inability to determine the structure of the buffer-insoluble Nogo extracellular domain retarded further design of Nogo receptor (NgR) antagonists to treat CNS axonal injuries. Very surprisingly, we recently discovered that Nogo-60 was soluble and structured in salt-free water, thus allowing the determination of the first Nogo structure by heteronuclear NMR spectroscopy. Nogo-60 adopts an unusual helical structure with the N- and C-terminal helices connected by a long middle helix. While the N-helix has no contact with the rest of the molecule, the C-helix flips back to pack against the 20-residue middle helix. This packing appears to trigger the formation of the stable Nogo-60 structure because Nogo-40 with the last helix truncated is unstructured. The Nogo-60 structure offered us rationales for further design of the structured and buffer-soluble Nogo-54, which may be used as a novel NgR antagonist. Furthermore, our discovery may imply a general solution to solubilizing a category of buffer-insoluble proteins for urgent structural investigations.

About this Structure

2G31 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Nogo goes in the pure water: solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regeneration., Li M, Liu J, Song J, Protein Sci. 2006 Aug;15(8):1835-41. PMID:16877707 Page seeded by OCA on Sun May 4 04:37:57 2008

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