2g6w
From Proteopedia
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[[Image:2g6w.gif|left|200px]] | [[Image:2g6w.gif|left|200px]] | ||
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'''Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine''' | '''Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine''' | ||
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[[Category: Alexeev, D.]] | [[Category: Alexeev, D.]] | ||
[[Category: 8-amino-7-oxonanoate]] | [[Category: 8-amino-7-oxonanoate]] | ||
- | [[Category: | + | [[Category: Biotin]] |
- | [[Category: | + | [[Category: Fluoroalanine]] |
- | [[Category: | + | [[Category: Plp]] |
- | [[Category: | + | [[Category: Synthase]] |
- | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:45:27 2008'' | |
- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + |
Revision as of 01:45, 4 May 2008
Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine
Overview
The irreversible inhibition of 8-amino-7-oxononanoate synthase by trifluoroalanine involves decarboxylative defluorination of the inhibitor-PLP aldimine followed by attack of the conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate which can subsequently undergo further HF losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl protein adduct.
About this Structure
2G6W is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine., Alexeev D, Baxter RL, Campopiano DJ, Kerbarh O, Sawyer L, Tomczyk N, Watt R, Webster SP, Org Biomol Chem. 2006 Apr 7;4(7):1209-12. Epub 2006 Mar 1. PMID:16557306 Page seeded by OCA on Sun May 4 04:45:27 2008