2g6w

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[[Image:2g6w.gif|left|200px]]
[[Image:2g6w.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2g6w |SIZE=350|CAPTION= <scene name='initialview01'>2g6w</scene>, resolution 2.14&Aring;
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The line below this paragraph, containing "STRUCTURE_2g6w", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=LLF:(4-{(E)-[(2,2-DIFLUOROETHYL)IMINO]METHYL}-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>LLF</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/8-amino-7-oxononanoate_synthase 8-amino-7-oxononanoate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.47 2.3.1.47] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2g6w| PDB=2g6w | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g6w OCA], [http://www.ebi.ac.uk/pdbsum/2g6w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g6w RCSB]</span>
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}}
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'''Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine'''
'''Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine'''
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[[Category: Alexeev, D.]]
[[Category: Alexeev, D.]]
[[Category: 8-amino-7-oxonanoate]]
[[Category: 8-amino-7-oxonanoate]]
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[[Category: biotin]]
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[[Category: Biotin]]
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[[Category: fluoroalanine]]
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[[Category: Fluoroalanine]]
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[[Category: plp]]
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[[Category: Plp]]
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[[Category: synthase]]
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[[Category: Synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:45:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:12:40 2008''
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Revision as of 01:45, 4 May 2008

Image:2g6w.gif

Template:STRUCTURE 2g6w

Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine


Overview

The irreversible inhibition of 8-amino-7-oxononanoate synthase by trifluoroalanine involves decarboxylative defluorination of the inhibitor-PLP aldimine followed by attack of the conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate which can subsequently undergo further HF losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl protein adduct.

About this Structure

2G6W is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine., Alexeev D, Baxter RL, Campopiano DJ, Kerbarh O, Sawyer L, Tomczyk N, Watt R, Webster SP, Org Biomol Chem. 2006 Apr 7;4(7):1209-12. Epub 2006 Mar 1. PMID:16557306 Page seeded by OCA on Sun May 4 04:45:27 2008

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