2g9t

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[[Image:2g9t.gif|left|200px]]
[[Image:2g9t.gif|left|200px]]
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{{Structure
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|PDB= 2g9t |SIZE=350|CAPTION= <scene name='initialview01'>2g9t</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_2g9t", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_2g9t| PDB=2g9t | SCENE= }}
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|RELATEDENTRY=[[2ga6|2GA6]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9t OCA], [http://www.ebi.ac.uk/pdbsum/2g9t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g9t RCSB]</span>
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'''Crystal structure of the SARS coronavirus nsp10 at 2.1A'''
'''Crystal structure of the SARS coronavirus nsp10 at 2.1A'''
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[[Category: Sun, F.]]
[[Category: Sun, F.]]
[[Category: Yang, H.]]
[[Category: Yang, H.]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: nsp10]]
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[[Category: Nsp10]]
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[[Category: sar]]
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[[Category: Sar]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:51:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:13:44 2008''
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Revision as of 01:51, 4 May 2008

Image:2g9t.gif

Template:STRUCTURE 2g9t

Crystal structure of the SARS coronavirus nsp10 at 2.1A


Overview

The severe acute respiratory syndrome coronavirus (SARS-CoV) nonstructural proteins nsp1 to nsp16 have been implicated by genetic analysis in the assembly of a functional replication/transcription complex. We report the crystal structure of nsp10 from SARS-CoV at 2.1-A resolution. The nsp10 structure has a novel fold, and 12 identical subunits assemble to form a unique spherical dodecameric architecture. Two zinc fingers have been identified from the nsp10 monomer structure with the sequence motifs C-(X)2-C-(X)5-H-(X)6-C and C-(X)2-C-(X)7-C-(X)-C. The nsp10 crystal structure is the first of a new class of zinc finger protein three-dimensional structures to be revealed experimentally. The zinc finger sequence motifs are conserved among all three coronavirus antigenic groups, implicating an essential function for nsp10 in all coronaviruses. Based on the structure, we propose that nsp10 is a transcription factor for coronavirus replication/transcription.

About this Structure

2G9T is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.

Reference

Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10., Su D, Lou Z, Sun F, Zhai Y, Yang H, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z, J Virol. 2006 Aug;80(16):7902-8. PMID:16873247 Page seeded by OCA on Sun May 4 04:51:49 2008

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