2gdo

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[[Image:2gdo.jpg|left|200px]]
[[Image:2gdo.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2gdo |SIZE=350|CAPTION= <scene name='initialview01'>2gdo</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2gdo", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=12C:4-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YLAMINO]-3-(1H-BENZIMIDAZOL-2-YL)-6-CHLOROQUINOLIN-2(1H)-ONE'>12C</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CHK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2gdo| PDB=2gdo | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gdo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gdo OCA], [http://www.ebi.ac.uk/pdbsum/2gdo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gdo RCSB]</span>
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}}
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'''4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors'''
'''4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors'''
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[[Category: Fang, E.]]
[[Category: Fang, E.]]
[[Category: Le, V.]]
[[Category: Le, V.]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: dna damage]]
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[[Category: Dna damage]]
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[[Category: drug design]]
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[[Category: Drug design]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:59:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:15:16 2008''
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Revision as of 01:59, 4 May 2008

Image:2gdo.jpg

Template:STRUCTURE 2gdo

4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors


Overview

CHK-1 is one of the key enzymes regulating checkpoints in cellular growth cycles. Novel 4-(amino-alkylamino)-3-benzimidazole-quinolinones were prepared and assayed for their ability to inhibit CHK-1. These compounds are potent cell permeable CHK-1 inhibitors and showed synergistic effect with a DNA-damaging agent, camptothecin.

About this Structure

2GDO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors., Ni ZJ, Barsanti P, Brammeier N, Diebes A, Poon DJ, Ng S, Pecchi S, Pfister K, Renhowe PA, Ramurthy S, Wagman AS, Bussiere DE, Le V, Zhou Y, Jansen JM, Ma S, Gesner TG, Bioorg Med Chem Lett. 2006 Jun 15;16(12):3121-4. Epub 2006 Apr 5. PMID:16603354 Page seeded by OCA on Sun May 4 04:59:03 2008

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OCA

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