2ggm

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[[Image:2ggm.gif|left|200px]]
[[Image:2ggm.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_2ggm", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|GENE= CETN2, CALT, CEN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2ggm| PDB=2ggm | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ggm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggm OCA], [http://www.ebi.ac.uk/pdbsum/2ggm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ggm RCSB]</span>
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'''Human centrin 2 xeroderma pigmentosum group C protein complex'''
'''Human centrin 2 xeroderma pigmentosum group C protein complex'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Thompson, J R.]]
[[Category: Thompson, J R.]]
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[[Category: dna repair complex]]
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[[Category: Dna repair complex]]
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[[Category: ef-hand superfamily]]
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[[Category: Ef-hand superfamily]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:05:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:16:25 2008''
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Revision as of 02:05, 4 May 2008

Image:2ggm.gif

Template:STRUCTURE 2ggm

Human centrin 2 xeroderma pigmentosum group C protein complex


Overview

Human centrin-2 plays a key role in centrosome function and stimulates nucleotide excision repair by binding to the xeroderma pigmentosum group C protein. To determine the structure of human centrin-2 and to develop an understanding of molecular interactions between centrin and xeroderma pigmentosum group C protein, we characterized the crystal structure of calcium-loaded full-length centrin-2 complexed with a xeroderma pigmentosum group C peptide. Our structure shows that the carboxyl-terminal domain of centrin-2 binds this peptide and two calcium atoms, whereas the amino-terminal lobe is in a closed conformation positioned distantly by an ordered alpha-helical linker. A stretch of the amino-terminal domain unique to centrins appears disordered. Two xeroderma pigmentosum group C peptides both bound to centrin-2 also interact to form an alpha-helical coiled-coil. The interface between centrin-2 and each peptide is predominantly nonpolar, and key hydrophobic residues of XPC have been identified that lead us to propose a novel binding motif for centrin.

About this Structure

2GGM is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the human centrin 2-xeroderma pigmentosum group C protein complex., Thompson JR, Ryan ZC, Salisbury JL, Kumar R, J Biol Chem. 2006 Jul 7;281(27):18746-52. Epub 2006 Apr 20. PMID:16627479 Page seeded by OCA on Sun May 4 05:05:07 2008

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