2gh0

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[[Image:2gh0.gif|left|200px]]
[[Image:2gh0.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2gh0 |SIZE=350|CAPTION= <scene name='initialview01'>2gh0</scene>, resolution 1.92&Aring;
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The line below this paragraph, containing "STRUCTURE_2gh0", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= GFRA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2gh0| PDB=2gh0 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gh0 OCA], [http://www.ebi.ac.uk/pdbsum/2gh0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gh0 RCSB]</span>
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'''Growth factor/receptor complex'''
'''Growth factor/receptor complex'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Wang, X Q.]]
[[Category: Wang, X Q.]]
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[[Category: cystine-knot]]
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[[Category: Cystine-knot]]
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[[Category: helix bundle]]
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[[Category: Helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:05:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:16:29 2008''
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Revision as of 02:05, 4 May 2008

Image:2gh0.gif

Template:STRUCTURE 2gh0

Growth factor/receptor complex


Overview

Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET receptor. It represents a new receptor-ligand interaction mode for the TGF-beta superfamily that reveals both conserved and specificity-determining anchor points for all GFL-GFRalpha pairs. In tandem with the complex structure, cellular studies using receptor chimeras implicate dyad-symmetric composite interfaces for recruitment and dimerization of RET, leading to intracellular signaling. These studies should facilitate the functional dissection of the specific versus pleiotropic roles of this system in neurobiology, as well as its exploitation for therapeutic applications.

About this Structure

2GH0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors., Wang X, Baloh RH, Milbrandt J, Garcia KC, Structure. 2006 Jun;14(6):1083-92. PMID:16765900 Page seeded by OCA on Sun May 4 05:05:53 2008

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