2giz

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[[Image:2giz.gif|left|200px]]
[[Image:2giz.gif|left|200px]]
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{{Structure
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{{STRUCTURE_2giz| PDB=2giz | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [http://www.ebi.ac.uk/pdbsum/2giz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB]</span>
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'''Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels'''
'''Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels'''
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[[Category: Yin, C.]]
[[Category: Yin, C.]]
[[Category: Zhou, Y.]]
[[Category: Zhou, Y.]]
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[[Category: blocker]]
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[[Category: Blocker]]
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[[Category: crisp]]
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[[Category: Crisp]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: docking]]
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[[Category: Docking]]
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[[Category: electrophysiology]]
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[[Category: Electrophysiology]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:09:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:17:16 2008''
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Revision as of 02:09, 4 May 2008

Image:2giz.gif

Template:STRUCTURE 2giz

Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels


Overview

Cysteine-rich secretory proteins (CRISPs) are secreted single-chain proteins found in different sources. Natrin is a member of the CRISP family purified from the snake venom of Naja naja atra, which has been reported as a BKca channel blocker. In our study, crystals of natrin were obtained in two different crystal forms and the structure of one of them was solved at a resolution of 1.68A. Our electrophysiological experiments indicated that natrin can block the ion channel currents of the voltage-gated potassium channel Kv1.3. Docking analyses of the interaction between natrin and Kv1.3 revealed a novel interaction pattern different from the two previously reported K(+) channel inhibition models termed "functional dyad" and "basic ring". These findings offered new insights into the function of natrin and how the specific interactions between CRISPs and different ion channels can be achieved.

About this Structure

2GIZ is a Single protein structure of sequence from Naja atra. Full crystallographic information is available from OCA.

Reference

Structural and functional analysis of natrin, a venom protein that targets various ion channels., Wang F, Li H, Liu MN, Song H, Han HM, Wang QL, Yin CC, Zhou YC, Qi Z, Shu YY, Lin ZJ, Jiang T, Biochem Biophys Res Commun. 2006 Dec 15;351(2):443-8. Epub 2006 Oct 20. PMID:17070778 Page seeded by OCA on Sun May 4 05:09:38 2008

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