2gj7

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[[Image:2gj7.gif|left|200px]]
[[Image:2gj7.gif|left|200px]]
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{{Structure
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|PDB= 2gj7 |SIZE=350|CAPTION= <scene name='initialview01'>2gj7</scene>, resolution 5.&Aring;
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The line below this paragraph, containing "STRUCTURE_2gj7", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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|GENE= IgG1 heavy chain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), GE, US8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10298 Human herpesvirus 1])
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|DOMAIN=
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{{STRUCTURE_2gj7| PDB=2gj7 | SCENE= }}
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|RELATEDENTRY=[[2giy|2GIY]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gj7 OCA], [http://www.ebi.ac.uk/pdbsum/2gj7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gj7 RCSB]</span>
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'''Crystal Structure of a gE-gI/Fc complex'''
'''Crystal Structure of a gE-gI/Fc complex'''
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[[Category: Sprague, E R.]]
[[Category: Sprague, E R.]]
[[Category: Wang, C.]]
[[Category: Wang, C.]]
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[[Category: fc receptor]]
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[[Category: Fc receptor]]
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[[Category: low resolution]]
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[[Category: Low resolution]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:10:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:17:20 2008''
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Revision as of 02:10, 4 May 2008

Image:2gj7.gif

Template:STRUCTURE 2gj7

Crystal Structure of a gE-gI/Fc complex


Overview

Herpes simplex virus type-1 expresses a heterodimeric Fc receptor, gE-gI, on the surfaces of virions and infected cells that binds the Fc region of host immunoglobulin G and is implicated in the cell-to-cell spread of virus. gE-gI binds immunoglobulin G at the basic pH of the cell surface and releases it at the acidic pH of lysosomes, consistent with a role in facilitating the degradation of antiviral antibodies. Here we identify the C-terminal domain of the gE ectodomain (CgE) as the minimal Fc-binding domain and present a 1.78-angstroms CgE structure. A 5-angstroms gE-gI/Fc crystal structure, which was independently verified by a theoretical prediction method, reveals that CgE binds Fc at the C(H)2-C(H)3 interface, the binding site for several mammalian and bacterial Fc-binding proteins. The structure identifies interface histidines that may confer pH-dependent binding and regions of CgE implicated in cell-to-cell spread of virus. The ternary organization of the gE-gI/Fc complex is compatible with antibody bipolar bridging, which can interfere with the antiviral immune response.

About this Structure

2GJ7 is a Protein complex structure of sequences from Cricetulus griseus, Homo sapiens and Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging., Sprague ER, Wang C, Baker D, Bjorkman PJ, PLoS Biol. 2006 Jun;4(6):e148. Epub 2006 May 2. PMID:16646632 Page seeded by OCA on Sun May 4 05:10:02 2008

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