2ocp
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(New page: 200px<br /> <applet load="2ocp" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ocp, resolution 2.80Å" /> '''Crystal Structure o...)
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Revision as of 21:02, 12 November 2007
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Crystal Structure of Human Deoxyguanosine Kinase
Contents |
Overview
Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides and, activate a number of medically important nucleoside analogs. Here we, report the structure of the Drosophila deoxyribonucleoside kinase with, deoxycytidine bound at the nucleoside binding site and that of the human, deoxyguanosine kinase with ATP at the nucleoside substrate binding site., Compared to the human kinase, the Drosophila kinase has a wider substrate, cleft, which may be responsible for the broad substrate specificity of, this enzyme. The human deoxyguanosine kinase is highly specific for purine, substrates; this is apparently due to the presence of Arg 118, which, provides favorable hydrogen bonding interactions with the substrate. The, two new structures provide an explanation for the substrate specificity of, cellular deoxyribonucleoside kinases.
Disease
Known diseases associated with this structure: Mitochondrial DNA-depletion syndrome, hepatocerebral form OMIM:[601465]
About this Structure
2OCP is a Single protein structure of sequence from Homo sapiens with DTP as ligand. This structure superseeds the now removed PDB entry 1JAG. Active as Deoxyguanosine kinase, with EC number 2.7.1.113 Full crystallographic information is available from OCA.
Reference
Structural basis for substrate specificities of cellular deoxyribonucleoside kinases., Johansson K, Ramaswamy S, Ljungcrantz C, Knecht W, Piskur J, Munch-Petersen B, Eriksson S, Eklund H, Nat Struct Biol. 2001 Jul;8(7):616-20. PMID:11427893
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