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2gl7

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[[Image:2gl7.jpg|left|200px]]
[[Image:2gl7.jpg|left|200px]]
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{{Structure
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|GENE= CTNNB1, CTNNB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), TCF7L2, TCF4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), BCL9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2gl7| PDB=2gl7 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gl7 OCA], [http://www.ebi.ac.uk/pdbsum/2gl7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gl7 RCSB]</span>
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'''Crystal Structure of a beta-catenin/BCL9/Tcf4 complex'''
'''Crystal Structure of a beta-catenin/BCL9/Tcf4 complex'''
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Sampietro, J.]]
[[Category: Sampietro, J.]]
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[[Category: armadillo repeat]]
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[[Category: Armadillo repeat]]
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[[Category: protein complex]]
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[[Category: Protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:13:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:18:04 2008''
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Revision as of 02:13, 4 May 2008

Image:2gl7.jpg

Template:STRUCTURE 2gl7

Crystal Structure of a beta-catenin/BCL9/Tcf4 complex


Overview

The canonical Wnt pathway plays critical roles in embryonic development, stem cell growth, and tumorigenesis. Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus, resulting in the transactivation of Wnt target genes. We have determined the crystal structure of a beta-catenin/BCL9/Tcf-4 triple complex at 2.6 A resolution. Our studies reveal that the beta-catenin binding site of BCL9 is distinct from that of most other beta-catenin partners and forms a good target for developing drugs that block canonical Wnt/beta-catenin signaling. The BCL9 beta-catenin binding domain (CBD) forms an alpha helix that binds to the first armadillo repeat of beta-catenin, which can be mutated to prevent beta-catenin binding to BCL9 without affecting cadherin or alpha-catenin binding. We also demonstrate that beta-catenin Y142 phosphorylation, which has been proposed to regulate BCL9-2 binding, does not directly affect the interaction of beta-catenin with either BCL9 or BCL9-2.

About this Structure

2GL7 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a beta-catenin/BCL9/Tcf4 complex., Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W, Mol Cell. 2006 Oct 20;24(2):293-300. PMID:17052462 Page seeded by OCA on Sun May 4 05:13:44 2008

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