2gli

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[[Image:2gli.jpg|left|200px]]
[[Image:2gli.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2gli |SIZE=350|CAPTION= <scene name='initialview01'>2gli</scene>, resolution 2.600&Aring;
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The line below this paragraph, containing "STRUCTURE_2gli", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= GLI ONCOGENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2gli| PDB=2gli | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gli FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gli OCA], [http://www.ebi.ac.uk/pdbsum/2gli PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gli RCSB]</span>
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}}
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'''FIVE-FINGER GLI/DNA COMPLEX'''
'''FIVE-FINGER GLI/DNA COMPLEX'''
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[[Category: Pabo, C O.]]
[[Category: Pabo, C O.]]
[[Category: Pavletich, N P.]]
[[Category: Pavletich, N P.]]
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[[Category: protein/dna complex]]
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[[Category: Protein/dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:14:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:18:14 2008''
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Revision as of 02:14, 4 May 2008

Image:2gli.jpg

Template:STRUCTURE 2gli

FIVE-FINGER GLI/DNA COMPLEX


Overview

Zinc finger proteins, of the type first discovered in transcription factor IIIA (TFIIIA), are one of the largest and most important families of DNA-binding proteins. The crystal structure of a complex containing the five Zn fingers from the human GLI oncogene and a high-affinity DNA binding site has been determined at 2.6 A resolution. Finger one does not contact the DNA. Fingers two through five bind in the major groove and wrap around the DNA, but lack the simple, strictly periodic arrangement observed in the Zif268 complex. Fingers four and five of GLI make extensive base contacts in a conserved nine base-pair region, and this section of the DNA has a conformation intermediate between B-DNA and A-DNA. Analyzing the GLI complex and comparing it with Zif268 offers new perspectives on Zn finger-DNA recognition.

About this Structure

2GLI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers., Pavletich NP, Pabo CO, Science. 1993 Sep 24;261(5129):1701-7. PMID:8378770 Page seeded by OCA on Sun May 4 05:14:30 2008

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OCA

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