2of4
From Proteopedia
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(New page: 200px<br /> <applet load="2of4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2of4, resolution 2.7Å" /> '''crystal structure of...)
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Revision as of 21:03, 12 November 2007
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crystal structure of furanopyrimidine 1 bound to lck
Contents |
Overview
2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and, selective inhibitors of Lck. The discovery, synthesis, and structure, activity relationships of this series of inhibitors are reported. The most, promising compounds were also profiled to deduce their pharmacokinetic, properties.
Disease
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]
About this Structure
2OF4 is a Single protein structure of sequence from Homo sapiens with 979 as ligand. Active as Non-specific protein-tyrosine kinase, with EC number 2.7.10.2 Full crystallographic information is available from OCA.
Reference
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties., Martin MW, Newcomb J, Nunes JJ, Bemis JE, McGowan DC, White RD, Buchanan JL, Dimauro EF, Boucher C, Faust T, Hsieh F, Huang X, Lee JH, Schneider S, Turci SM, Zhu X, Bioorg Med Chem Lett. 2007 Apr 15;17(8):2299-304. Epub 2007 Jan 24. PMID:17276681
Page seeded by OCA on Mon Nov 12 23:10:16 2007
