2gom
From Proteopedia
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'''Crystal structure of Efb-C from Staphylococcus aureus''' | '''Crystal structure of Efb-C from Staphylococcus aureus''' | ||
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[[Category: Geisbrecht, B V.]] | [[Category: Geisbrecht, B V.]] | ||
[[Category: Hammel, M.]] | [[Category: Hammel, M.]] | ||
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Revision as of 02:20, 4 May 2008
Crystal structure of Efb-C from Staphylococcus aureus
Overview
To provide insight into bacterial suppression of complement-mediated immunity, we present here structures of a bacterial complement inhibitory protein, both free and bound to its complement target. The 1.25-A structure of the complement component C3-inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb-C) demonstrated a helical motif involved in complement regulation, whereas the 2.2-A structure of Efb-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided evidence for a previously unrecognized mode of complement inhibition whereby Efb-C binds to native C3 and alters the solution conformation of C3 in a way that renders it unable to participate in successful 'downstream' activation of the complement response.
About this Structure
2GOM is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
A structural basis for complement inhibition by Staphylococcus aureus., Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV, Nat Immunol. 2007 Apr;8(4):430-7. Epub 2007 Mar 11. PMID:17351618 Page seeded by OCA on Sun May 4 05:20:33 2008
