2grx

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[[Image:2grx.gif|left|200px]]
[[Image:2grx.gif|left|200px]]
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{{Structure
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|PDB= 2grx |SIZE=350|CAPTION= <scene name='initialview01'>2grx</scene>, resolution 3.300&Aring;
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The line below this paragraph, containing "STRUCTURE_2grx", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=EAP:2-AMINO-VINYL-PHOSPHATE'>EAP</scene>, <scene name='pdbligand=FCI:FERRICROCIN-IRON'>FCI</scene>, <scene name='pdbligand=FTT:3-HYDROXY-TETRADECANOIC+ACID'>FTT</scene>, <scene name='pdbligand=GCN:3-DEOXY-D-GLUCOSAMINE'>GCN</scene>, <scene name='pdbligand=GMH:L-GLYCERO-D-MANNO-HEPTOPYRANOSE'>GMH</scene>, <scene name='pdbligand=KDO:3-DEOXY-D-MANNO-OCT-2-ULOSONIC+ACID'>KDO</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= fhuA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), tonB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_2grx| PDB=2grx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2grx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2grx OCA], [http://www.ebi.ac.uk/pdbsum/2grx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2grx RCSB]</span>
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'''Crystal structure of TonB in complex with FhuA, E. coli outer membrane receptor for ferrichrome'''
'''Crystal structure of TonB in complex with FhuA, E. coli outer membrane receptor for ferrichrome'''
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[[Category: Coulton, J W.]]
[[Category: Coulton, J W.]]
[[Category: Pawelek, P D.]]
[[Category: Pawelek, P D.]]
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[[Category: beta barrel]]
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[[Category: Beta barrel]]
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[[Category: heterocomplex]]
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[[Category: Heterocomplex]]
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[[Category: inter-protein beta sheet]]
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[[Category: Inter-protein beta sheet]]
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[[Category: outer membrane]]
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[[Category: Outer membrane]]
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[[Category: protein-protein]]
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[[Category: Protein-protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:26:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:20:38 2008''
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Revision as of 02:26, 4 May 2008

Image:2grx.gif

Template:STRUCTURE 2grx

Crystal structure of TonB in complex with FhuA, E. coli outer membrane receptor for ferrichrome


Overview

The cytoplasmic membrane protein TonB spans the periplasm of the Gram-negative bacterial cell envelope, contacts cognate outer membrane receptors, and facilitates siderophore transport. The outer membrane receptor FhuA from Escherichia coli mediates TonB-dependent import of ferrichrome. We report the 3.3 angstrom resolution crystal structure of the TonB carboxyl-terminal domain in complex with FhuA. TonB contacts stabilize FhuA's amino-terminal residues, including those of the consensus Ton box sequence that form an interprotein beta sheet with TonB through strand exchange. The highly conserved TonB residue arginine-166 is oriented to form multiple contacts with the FhuA cork, the globular domain enclosed by the beta barrel.

About this Structure

2GRX is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of TonB in complex with FhuA, E. coli outer membrane receptor., Pawelek PD, Croteau N, Ng-Thow-Hing C, Khursigara CM, Moiseeva N, Allaire M, Coulton JW, Science. 2006 Jun 2;312(5778):1399-402. PMID:16741125 Page seeded by OCA on Sun May 4 05:26:56 2008

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