2gsk

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[[Image:2gsk.gif|left|200px]]
[[Image:2gsk.gif|left|200px]]
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{{Structure
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|PDB= 2gsk |SIZE=350|CAPTION= <scene name='initialview01'>2gsk</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_2gsk", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CNC:CO-CYANOCOBALAMIN'>CNC</scene>, <scene name='pdbligand=HEX:HEXANE'>HEX</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= btuB, bfe, cer, dcrC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), tonB, exbA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_2gsk| PDB=2gsk | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gsk OCA], [http://www.ebi.ac.uk/pdbsum/2gsk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gsk RCSB]</span>
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'''Structure of the BtuB:TonB Complex'''
'''Structure of the BtuB:TonB Complex'''
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[[Category: Shultis, D D.]]
[[Category: Shultis, D D.]]
[[Category: Wiener, M C.]]
[[Category: Wiener, M C.]]
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[[Category: beta-barrel]]
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[[Category: Beta-barrel]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: outer-membrane active transport]]
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[[Category: Outer-membrane active transport]]
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[[Category: tonb]]
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[[Category: Tonb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:28:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:20:56 2008''
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Revision as of 02:28, 4 May 2008

Image:2gsk.gif

Template:STRUCTURE 2gsk

Structure of the BtuB:TonB Complex


Overview

In Gram-negative bacteria, the import of essential micronutrients across the outer membrane requires a transporter, an electrochemical gradient of protons across the inner membrane, and an inner membrane protein complex (ExbB, ExbD, TonB) that couples the proton-motive force to the outer membrane transporter. The inner membrane protein TonB binds directly to a conserved region, called the Ton-box, of the transporter. We solved the structure of the cobalamin transporter BtuB in complex with the C-terminal domain of TonB. In contrast to its conformations in the absence of TonB, the Ton-box forms a beta strand that is recruited to the existing beta sheet of TonB, which is consistent with a mechanical pulling model of transport.

About this Structure

2GSK is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Outer membrane active transport: structure of the BtuB:TonB complex., Shultis DD, Purdy MD, Banchs CN, Wiener MC, Science. 2006 Jun 2;312(5778):1396-9. PMID:16741124 Page seeded by OCA on Sun May 4 05:28:34 2008

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