2gtt
From Proteopedia
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[[Image:2gtt.gif|left|200px]] | [[Image:2gtt.gif|left|200px]] | ||
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'''Crystal structure of the rabies virus nucleoprotein-RNA complex''' | '''Crystal structure of the rabies virus nucleoprotein-RNA complex''' | ||
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[[Category: Weissenhorn, W.]] | [[Category: Weissenhorn, W.]] | ||
[[Category: Wernimont, A K.]] | [[Category: Wernimont, A K.]] | ||
| - | [[Category: | + | [[Category: Nucleoprotein]] |
| - | [[Category: | + | [[Category: Protein-rna complex]] |
| - | [[Category: | + | [[Category: Rabies virus]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:31:37 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 02:31, 4 May 2008
Crystal structure of the rabies virus nucleoprotein-RNA complex
Overview
Negative-strand RNA viruses condense their genome into a helical nucleoprotein-RNA complex, the nucleocapsid, which is packed into virions and serves as a template for the RNA-dependent RNA polymerase complex. The crystal structure of a recombinant rabies virus nucleoprotein-RNA complex, organized in an undecameric ring, has been determined at 3.5 angstrom resolution. Polymerization of the nucleoprotein is achieved by domain exchange between protomers, with flexible hinges allowing nucleocapsid formation. The two core domains of the nucleoprotein clamp around the RNA at their interface and shield it from the environment. RNA sequestering by nucleoproteins is likely a common mechanism used by negative-strand RNA viruses to protect their genomes from the innate immune response directed against viral RNA in human host cells at certain stages of an infectious cycle.
About this Structure
2GTT is a Single protein structure of sequence from Rabies virus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the rabies virus nucleoprotein-RNA complex., Albertini AA, Wernimont AK, Muziol T, Ravelli RB, Clapier CR, Schoehn G, Weissenhorn W, Ruigrok RW, Science. 2006 Jul 21;313(5785):360-3. Epub 2006 Jun 15. PMID:16778023 Page seeded by OCA on Sun May 4 05:31:37 2008
