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2gv2

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[[Image:2gv2.gif|left|200px]]
[[Image:2gv2.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2gv2 |SIZE=350|CAPTION= <scene name='initialview01'>2gv2</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2gv2", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=1AC:1-AMINOCYCLOPROPANECARBOXYLIC+ACID'>1AC</scene>, <scene name='pdbligand=6CW:6-CHLORO-L-TRYPTOPHAN'>6CW</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=PM3:2-AMINO-3-(4-PHOSPHONOMETHYL-PHENYL)-PROPIONIC+ACID'>PM3</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= MDM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2gv2| PDB=2gv2 | SCENE= }}
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|RELATEDENTRY=[[1ycr|1YCR]], [[1t4f|1T4F]], [[1t4e|1T4E]], [[1rv1|1RV1]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gv2 OCA], [http://www.ebi.ac.uk/pdbsum/2gv2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gv2 RCSB]</span>
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}}
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'''MDM2 in complex with an 8-mer p53 peptide analogue'''
'''MDM2 in complex with an 8-mer p53 peptide analogue'''
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[[Category: Sakurai, K.]]
[[Category: Sakurai, K.]]
[[Category: Schubert, C.]]
[[Category: Schubert, C.]]
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[[Category: optimized protein-protein interaction. synthetic peptide. alpha helix binding protein]]
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[[Category: Optimized protein-protein interaction. synthetic peptide. alpha helix binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:34:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:21:58 2008''
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Revision as of 02:34, 4 May 2008

Image:2gv2.gif

Template:STRUCTURE 2gv2

MDM2 in complex with an 8-mer p53 peptide analogue


Overview

The most potent inhibitor of the p53-MDM2 interaction reported to date is an 8-mer p53 peptide analogue (Novartis peptide), which contains 6-chlorotryptophane (Cl-Trp) and phosphonomethylphenylalanine (Pmp) as key residues for the enhanced activity. We report here a crystal structure of the co-complex between MDM2 and the Novartis peptide solved at 1.8 A resolution. The structural basis for the role of the two aromatic residues are delineated by comparing the present structure with crystal structures of the MDM2 co-complex bound to other inhibitors including the wt-p53 peptide itself.

About this Structure

2GV2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of an 8-mer p53 peptide analogue complexed with MDM2., Sakurai K, Schubert C, Kahne D, J Am Chem Soc. 2006 Aug 30;128(34):11000-1. PMID:16925398 Page seeded by OCA on Sun May 4 05:34:22 2008

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