2gw1

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[[Image:2gw1.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_2gw1", creates the "Structure Box" on the page.
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|GENE= TOM70, MAS70, OMP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gw1 OCA], [http://www.ebi.ac.uk/pdbsum/2gw1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gw1 RCSB]</span>
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'''Crystal Structure of the Yeast Tom70'''
'''Crystal Structure of the Yeast Tom70'''
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[[Category: Sha, B.]]
[[Category: Sha, B.]]
[[Category: Wu, Y.]]
[[Category: Wu, Y.]]
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[[Category: tpr]]
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[[Category: Tpr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:36:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:22:24 2008''
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Revision as of 02:36, 4 May 2008

Image:2gw1.gif

Template:STRUCTURE 2gw1

Crystal Structure of the Yeast Tom70


Overview

A majority of the proteins targeted to the mitochondria are transported through the translocase of the outer membrane (TOM) complex. Tom70 is a major surface receptor for mitochondrial protein precursors in the TOM complex. To investigate how Tom70 receives the mitochondrial protein precursors, we have determined the crystal structure of yeast Tom70p to 3.0 A. Tom70p forms a homodimer in the crystal. Each subunit consists primarily of tetratricopeptide repeat (TPR) motifs, which are organized into a right-handed superhelix. The TPR motifs in the N-terminal domain of Tom70p form a peptide-binding groove for the C-terminal EEVD motif of Hsp70, whereas the C-terminal domain of Tom70p contains a large pocket that may be the binding site for mitochondrial precursors. The crystal structure of Tom70p provides insights into the mechanisms of precursor transport across the mitochondrion's outer membrane.

About this Structure

2GW1 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of yeast mitochondrial outer membrane translocon member Tom70p., Wu Y, Sha B, Nat Struct Mol Biol. 2006 Jul;13(7):589-93. Epub 2006 Jun 11. PMID:16767096 Page seeded by OCA on Sun May 4 05:36:20 2008

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